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Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules

Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules
人类非酒精性脂肪肝的阶段性治疗:阐明胰高血糖素样肽-1受体激动剂和新型抗纤维化分子的精确作用机制
批准号:
468757
负责人:
Gaisano Herbert Y
金额:
$81.37万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-09-01 至 2027-09-01

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中文摘要
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英文摘要
Non-alcoholic Fatty Liver Disease (NAFLD) is present in 30% of Canadians, reaching >70% in those with diabetes and obesity. Many progress from reversible stages of liver fat accumulation to inflammation (non-alcoholic steatohepatitis-NASH) and fibrosis; t
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Canada Research Chairs - Tier 1
  • 批准号:
    424778
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2019
  • 负责人:
    Gaisano Herbert Y
  • 依托单位:
Novel excitosomes mediating exocytosis in neuroendocrine cells
  • 批准号:
    379534
  • 项目类别:
    Operating Grants
  • 资助金额:
    $63.53万
  • 财政年份:
    2018
  • 负责人:
    Gaisano Herbert Y
  • 依托单位:
Role of autophagy dysregulation in pancreatitis caused by alcohol and glucagon-like peptide
  • 批准号:
    379648
  • 项目类别:
    Operating Grants
  • 资助金额:
    $64.93万
  • 财政年份:
    2018
  • 负责人:
    Gaisano Herbert Y
  • 依托单位:
alpha-cell glucagon secretion: regulated exocytosis, dysregulation & rescue of type-1 diabetes
  • 批准号:
    341268
  • 项目类别:
    Operating Grants
  • 资助金额:
    $57.09万
  • 财政年份:
    2016
  • 负责人:
    Gaisano Herbert Y
  • 依托单位:
海外基金