The trigeminal system: from receptor expression to the interaction with the sense of smell

三叉神经系统是仅次于嗅觉和味觉的第三种化学感觉系统。它允许感知不同的感觉，例如，辣椒的辛辣，薄荷的清新，芥末的辛辣。这种感觉系统独立于嗅觉和味觉。虽然它们在解剖学上是可分离的，但化学感觉在功能上是交织在一起的：首先，化学感觉刺激通常激活一个以上的化学感觉系统（例如，薄荷醇激活三叉神经系统并引起新鲜感，同时它还激活嗅觉系统并引起薄荷味）。其次，受体位于附近，并可能相互影响。最后，化学感觉在大脑中共享处理单元。因此，化学感觉，特别是嗅觉和三叉神经系统在感知气味和味道时相互作用。虽然我们现在对嗅觉了解很多，但对三叉神经系统如何工作，特别是它与嗅觉的相互作用知之甚少。对这种化学感觉系统的更深入理解是重要的，原因有几个：（1）三叉神经系统是味道和气味感知的重要贡献者。为了理解这些过程，更好地理解这个在很大程度上未知的化学感觉系统是至关重要的;（2）理解嗅觉和三叉神经系统之间的相互作用，理解这些系统在味道和嗅觉感知过程中如何相互作用同样重要;（3）嗅觉经历了对暴露和训练的反应变化。在自然嗅觉的大多数条件下，三叉神经系统与嗅觉系统一起被激活。三叉神经系统本身也会对反复的暴露和训练做出反应。由于几乎所有的气味也激活三叉神经系统，三叉神经系统的可塑性在嗅觉系统中的作用必须得到更好的理解。 因此，这一应用程序将支持我的三叉神经加工和感知的基本机制和三叉神经系统与嗅觉系统的相互作用的研究。

The trigeminal system is a third chemosensory system next to smell and taste. It allows for the perception of diverse sensations, e.g., the spiciness of hot peppers, the freshness of peppermint or the pungency of wasabi. This sensory system is independent from smell and taste. Although they are anatomically separable, the chemical senses are functionally intertwined: first, chemosensory stimuli usually activate more than one chemosensory system (e.g., menthol activates the trigeminal system and evokes a fresh sensation while it also activates the olfactory system and evokes a minty smell). Next, receptors are located in close vicinity and potentially influence each other. Finally, the chemical senses share processing units in the brain. Therefore, the chemical senses, and specifically, the olfactory and the trigeminal system interact mutually during the perception of odors and flavors. Although we now know a lot about the sense of smell, much less is known about how the trigeminal system works, especially its interaction with the sense of smell. A deeper understanding of this chemosensory system is important for several reasons: (1) the trigeminal system is an important contributor to flavor and smell perception.. To understand these processes a better comprehension of this largely unknown chemosensory system is crucial; (2) it is equally important to comprehend the interaction between the olfactory and the trigeminal systems, to understand how the systems interact during flavor and smell perception; (3) the sense of smell undergoes changes in response to exposure and training. During most conditions of natural smelling, the trigeminal system is activated together with the olfactory system. The trigeminal system itself also responds to repeated exposure and training. Since virtually all odorants also activate the trigeminal system, the trigeminal system's role in plasticity in the olfactory system must be better understood. This application will therefore support my research on basic mechanisms of trigeminal processing and perception and the trigeminal system's interaction with the olfactory system.