Dissection of the effects by extracellular hydrolysis products of triglycerides and phospholipids on cellular functions

甘油三酯和磷脂的细胞外水解产物对细胞功能的影响的剖析

• 批准号: RGPIN-2018-05359
• 负责人: Brown, Robert
• 金额: $ 2.33万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744068
• 关键词: Dissection; effects; extracellular; hydrolysis; products

Lipids have numerous biological functions. They are an important component of cell membranes, they can supply energy to cells, and they can affect biological functions in cells. Lipids that are obtained through diet, as well as some of the lipids that can be synthesized by cells, are transported in the circulation of all mammals by large complexes known as lipoproteins. Well known lipoproteins include LDL (the “bad cholesterol”) and HDL (the “good cholesterol”). The break-down of lipids in the circulation by a group of enzymes known as lipases results in the formation of “hydrolysis products”. These hydrolysis products include fatty acids. The hydrolysis products can be delivered from the circulation to cells. We previously showed that hydrolysis products can alter cell functions. Some of the altered functions may be beneficial and some may be detrimental to the normal function of cells. The focus of our NSERC-funded research is to understand the cell functions that are affected by hydrolysis products. Our studies will likely have a future impact in further understanding how lipids contribute at the cell level in a variety of ailments, such as obesity and heart disease.

脂质具有许多生物学功能。它们是细胞膜的重要组成部分，为细胞提供能量，影响细胞的生物功能。通过饮食获得的脂质，以及一些可以由细胞合成的脂质，通过称为脂蛋白的大复合物在所有哺乳动物的循环中运输。众所周知的脂蛋白包括低密度脂蛋白（“坏胆固醇”）和高密度脂蛋白（“好胆固醇”）。脂质在循环中被一组称为脂肪酶的酶分解，形成“水解产物”。这些水解产物包括脂肪酸。水解产物可以从循环输送到细胞。我们之前的研究表明，水解产物可以改变细胞功能。一些功能的改变可能是有益的，而另一些则可能对细胞的正常功能有害。我们nserc资助的研究的重点是了解受水解产物影响的细胞功能。我们的研究可能会对进一步了解脂质如何在细胞水平上对各种疾病（如肥胖和心脏病）起作用产生影响。