Identification of genes and signalling pathways modulated by extracellular hydrolysis products of triglycerides and phospholipids

甘油三酯和磷脂胞外水解产物调节的基因和信号通路的鉴定

• 批准号: 402185-2011
• 负责人: Brown, Robert
• 金额: $ 2.4万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596055
• 关键词: Identification; genes; signalling; pathways; modulated

Lipids are important components of cell membranes, can supply energy to cells, and can act as signalling molecules within cells to trigger biological functions. Lipids that are obtained through diet, as well as some of the lipids that can be synthesized by cells, are transported in the circulation in all mammals by large complexes known as lipoproteins (ie. the lipoproteins LDL - also known as 'bad cholesterol', and HDL - also known as 'good cholesterol'). The break-down in the circulation of triglycerides and phospholipids that are associated with lipoproteins by a group of enzymes known as lipases results in the formation of 'hydrolysis products', such as fatty acids. The hydrolysis products can be delivered from the circulation to cells. Some evidence exists to support the idea that specific hydrolysis products from the circulation might trigger biological functions - some of which may be beneficial and some of which may be detrimental to the normal function of cells. The focus of our NSERC-funded research is to understand the cell functions that are modulated by hydrolysis products following the action of lipases on lipoproteins. Our studies will likely have an impact in further understanding how lipids may contribute at the level of the cell to a variety of ailments, such as obesity and heart disease.

脂质是细胞膜的重要组成部分，可以为细胞提供能量，并可以作为细胞内的信号分子触发生物功能。通过饮食获得的脂质，以及一些可以由细胞合成的脂质，在所有哺乳动物的循环中通过称为脂蛋白的大复合物（即脂蛋白）运输。脂蛋白LDL -也称为“坏胆固醇”，和HDL -也称为“好胆固醇”）。在循环中，甘油三酯和磷脂与脂蛋白相关，通过一组称为脂肪酶的酶分解，导致形成“水解产物”，如脂肪酸。水解产物可以从循环输送到细胞。一些证据支持循环中的特定水解产物可能触发生物功能的想法-其中一些可能是有益的，其中一些可能对细胞的正常功能有害。我们NSERC资助的研究的重点是了解脂肪酶对脂蛋白作用后水解产物调节的细胞功能。我们的研究可能会对进一步了解脂质如何在细胞水平上对各种疾病（如肥胖和心脏病）产生影响。