Regulation of 5-methylcytosine upon the transition from naive to primed pluripotency

在人类发育过程中，某些基因在正确的时间被激活和失活至关重要。DNA甲基化有助于控制这一过程。某些被称为DNA甲基转移酶的酶化学修饰DNA以沉默需要关闭以使发育正确发生的基因。我将使用干细胞来研究DNA甲基转移酶在人类早期发育阶段是如何调节的，否则就不可能研究。我的研究将与某些疾病直接相关，如癌症和ICF综合征，这些疾病会发生DNA甲基化畸变，并将更广泛地帮助我们了解人类早期发育是如何控制的。此外，我将培养一个博士。使学生成为台架科学和计算分析方面的专家。

During human development, it is critical that certain genes be activated and inactivated at the right time. DNA methylation helps control this process. Certain enzymes called DNA methyltransferases chemically modify DNA to silence genes that need to be turned off for development to occur correctly. I will use stem cells to study how DNA methyltransferases are regulated during stages of early human development that would otherwise be impossible to study. My research will be directly relevant to certain diseases, such as cancer and ICF syndrome, where aberrations of DNA methylation occur and will more broadly help us understand how early human development is controlled. Additionally, I will train a Ph.D. student to become an expert in both bench science and computational analysis.