Hydrogel constructs to improve the stability of biologics in industrial applications

本项目旨在开发新型水凝胶包衣技术，以改善包括蛋白质和核酸在内的活性药物成分（api）在室温下的开发、纯化和保质期。这将通过用聚（维生素B5类似甲基丙烯酰胺）聚（B5AMA）水凝胶涂覆市售玻璃瓶和色谱树脂来实现。水凝胶包覆树脂将包括在原料药的生产批次中，以提高生物活性在苛刻的合成过程中的稳定性。生产的生物活性物质将储存在水凝胶涂覆的玻璃小瓶中，以确保产品在环境温度下的保质期更长。聚（B5AMA）水凝胶涂覆在玻璃小瓶上，有望为研究实验室、制药公司和卫生保健机构的活性药物治疗的快速合成、运输、储存和使用提供便利的商业化策略。

This project aims at developing novel hydrogel coating technology to improve the development, purification and shelf life of active pharmaceutical ingredients (APIs) including proteins and nucleic acids at ambient temperatures. This will be achieved by coating commercially available glass vials and chromatography resins with poly(vitamin B5 analogous methacrylamide) poly(B5AMA) hydrogels. The hydrogels coated resins will be included in production batches of APIs to improve the stability of bioactives under harsh synthesis procedure. The bioactives manufactured will be stored in hydrogels coated glass vials to ensure longer shelf life of the products at ambient temperatures. Poly(B5AMA) hydrogels coating on glass vials is expected to provide a convenient commercialization strategy for the facile synthesis, transport, storage and usage of active pharmaceutical therapeutics in research laboratories, pharmaceutical companies and in health care settings.