Hydrophilic Nano patterned Surfaces for Macrophage Polarization and Drug Delivery

用于巨噬细胞极化和药物输送的亲水性纳米图案表面

• 批准号: 576948-2022
• 负责人: Ahmed, MaryaM
• 金额: $ 1.82万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747283
• 关键词: Hydrophilic; Nano; patterned; Surfaces; Macrophage

This project aims to explore the potential of nanopatterned hydrophilic surfaces for enhanced wound healing. Nanopatterned hydrophilic surfaces prepared using Cicada wing as template will be loaded with antibacterial and immunomodulatory peptides. The release of peptides from surfaces, their integrity and antibacterial properties will be studied in vitro, in simulated wound fluid. The peptide loaded nanopatterned surfaces will be cultured in the presence of macrophages and macrophage polarization capabilities of the surfaces, in the presence and absence of peptides will be studied. The nanopatterned surfaces with enhanced macrophage polarization capabilities and antibacterial efficacies in the presence and absence of peptide loading will be identified.

该项目旨在探索纳米图案化亲水表面增强伤口愈合的潜力。使用蝉翅作为模板制备的纳米图案化亲水表面将负载有抗菌肽和免疫调节肽。肽从表面的释放、其完整性和抗菌特性将在体外模拟伤口液中进行研究。将在巨噬细胞的存在下培养负载肽的纳米图案化表面，并且将研究在肽的存在和不存在下表面的巨噬细胞极化能力。将鉴定在存在和不存在肽负载的情况下具有增强的巨噬细胞极化能力和抗菌功效的纳米图案化表面。