Hydrophilic Nano patterned Surfaces for Macrophage Polarization and Drug Delivery

该项目旨在探索纳米涂层亲水性表面在促进伤口愈合方面的潜力。以蝉翅为模板制备的纳米膜亲水表面将负载抗菌肽和免疫调节肽。将在体外模拟伤口液中研究多肽从表面的释放、它们的完整性和抗菌性能。将负载多肽的纳米颗粒表面在巨噬细胞存在和巨噬细胞极化能力的表面进行培养，在多肽存在和不存在的情况下进行研究。具有增强的巨噬细胞极化能力和在存在和不存在肽负载的情况下的抗菌效果的纳米颗粒表面将被识别。

This project aims to explore the potential of nanopatterned hydrophilic surfaces for enhanced wound healing. Nanopatterned hydrophilic surfaces prepared using Cicada wing as template will be loaded with antibacterial and immunomodulatory peptides. The release of peptides from surfaces, their integrity and antibacterial properties will be studied in vitro, in simulated wound fluid. The peptide loaded nanopatterned surfaces will be cultured in the presence of macrophages and macrophage polarization capabilities of the surfaces, in the presence and absence of peptides will be studied. The nanopatterned surfaces with enhanced macrophage polarization capabilities and antibacterial efficacies in the presence and absence of peptide loading will be identified.