Exploring the Molecular Chemistry of Selenium and Tellurium

探索硒和碲的分子化学

• 批准号: RGPIN-2019-06725
• 负责人: Ritch, Jamie
• 金额: $ 1.75万
• 依托单位: University of Winnipeg
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748067
• 关键词: Exploring; Molecular; Chemistry; Selenium; Tellurium

The elements selenium and tellurium have a wide range of industrial and consumer applications, from solar cell production and steel manufacture to anti-dandruff shampoos. Nature has evolved complex enzymes featuring selenium as a critical component in controlling biochemical reactions, making it an essential micronutrient. In contrast to its valuable role in biology, the use of the heavy chalcogens in man-made chemicals lags behind other common elements such as phosphorus and sulfur. Given this high potential for new discoveries, selenium and tellurium (known as the "heavy chalcogens") are being increasingly researched to find new applications. In 2015, Canada was the fourth-largest producer of these elements in the world, providing further incentive to explore the chemistry of these elements. The proposed research program will conduct investigations into the chemistry of new heavy chalcogen-containing ligands, which are molecules or ions that bind to metals. Studies of this nature exist in the literature, but they are relatively sparse, and often there is not enough data to correlate the structure of the ligands with their activity of the resulting metal complexes. We aim to prepare a library of related ligands, and systematically investigate their structure-activity relationships to establish protocols for the future rationale design of molecular metal complexes. The work will generate new discoveries of the fundamental chemistry of these ligands, which in turn will allow them to be incorporated into compounds with real-world applicability, such as catalysts for production of fine chemicals or pharmaceuticals, or improved light-harvesting materials. Training of highly-qualified personnel (HQP) will be of paramount importance in this study. 64% of the budget is dedicated to wages and stipends for a number of undergraduate and graduate student HQP, who will conduct this research and in turn learn valuable transferable skills. Developing strong research, communication, and problem-solving skills will allow them to transition to in-demand careers in government, academia, and industry.

这些元素硒和柜员具有广泛的工业和消费者应用，从太阳能电池生产和钢制造到抗dandruff洗发水。大自然已经进化了复合酶，这些酶以硒作为控制生化反应的关键成分，使其成为必不可少的微量营养素。与其在生物学中的有价值作用相反，在人造化学物质中使用重玉米成蛋白的作用落后于其他常见元素，例如磷和硫。鉴于新发现的这种高潜力，硒和柜员（称为“重型果酱”）正在越来越多地研究以找到新的应用。 2015年，加拿大是世界上这些元素中第四大生产商，提供了进一步的动力来探索这些元素的化学反应。 拟议的研究计划将对新的含chalcogen的新配体的化学性质进行研究，这些配体是与金属结合的分子或离子。文献中存在这种性质的研究，但它们相对较少，并且通常没有足够的数据将配体的结构与所得金属复合物的活性相关联。我们旨在准备一个相关配体的库，并系统地研究其结构活性关系，以建立分子金属复合物的未来理由设计方案。这项工作将产生这些配体基本化学的新发现，进而将它们纳入具有现实世界中适用性的化合物中，例如用于生产精细化学物质或药物的催化剂，或改进的轻度收获材​​料。在这项研究中，对高度合格人员（HQP）的培训将至关重要。预算的64％致力于许多本科和研究生HQP的工资和津贴，他们将进行这项研究，进而学习有价值的可转移技能。发展强大的研究，沟通和解决问题的技能将使他们能够过渡到政府，学术界和工业的需求。