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Characterizing huntingtin-deoxyribonucleic-acid binding interactions and somatic expansion in Huntington's disease

Characterizing huntingtin-deoxyribonucleic-acid binding interactions and somatic expansion in Huntington's disease
亨廷顿病中亨廷顿蛋白-脱氧核糖核酸结合相互作用和体细胞扩张的特征
批准号：
486570
负责人：
Alvarado Justin G
金额：
$1.27万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486570&lang=en
关键词：
Atm Kinase Fluorescent Microscopy Huntington'S Disease Mcmaster Center For Advanced Light Microscopy Nikon A1 Confocal And Widefield Devices Nsim Super-Resolution Nanoscope Primary Fibroblasts Programmed Induced Pluripotent Stem Cells Rpe1

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英文摘要
Huntington’s Disease (HD) is a devastating hereditary disease that progressively kills brain cells, causing cognitive, motor, and psychiatric decline. HD is caused by a mutation in a tract of DNA that encodes the huntingtin (HTT) protein which contains re
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