Pain Neuroimaging

疼痛神经影像学

• 批准号: CRC-2021-00364
• 负责人: Moayedi, Massieh
• 金额: $ 5.1万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=750692
• 关键词: Pain; Neuroimaging

Pain is a biopsychosocial experience, but most studies have focused solely on the biological domain, which cannot satisfactorily explain the pain experience. Like pain, body image, an individual's subjective experience of the size, shape, and features of their body, is biologically, psychologically, and socio-culturally constituted; accordingly, disturbances of body image have been reported in multiple disorders chronic pain disorders. Despite this connection, the relationship between body image and chronic pain has yet to be understood. Prof. Moayedi's proposed research will deepen our understandings of the intersection of pain and body image and identify novel therapeutic targets. by addressing 2 themes of research. The first theme will determine the relationship between body image and the pain experience using visual illusion that change the shape and size of an individual's body (e.g, a finger stretch illusion). This theme comprises three objectives which will (1) identify brain regions causally involved in finger stretch illusion; (2) determine whether changes to body image through the visual illusion alter sensitivity to an experimental model of pain; and (3) causally determine which brain regions involved in body image affect sensitivity to an experimental model of pain. These would identify potential new therapeutic targets for chronic pains associated with body image disturbances. Theme 2 will determine the relationship post-surgical pain and changes in body image. This theme comprises three objectives that will (3) explore the pain experience in transmen and cisgender women; (2) determine the relationship between BPD and pain; and (3) a mixed method analysis of BPD and pain relationship. This theme will investigate the pain experiences of ciswomen undergoing prophylactic mastectomy and transmen undergoing top surgery combining qualitative interviews with quantitative methods including behavioural, psychophysical and neuroimaging method. As the first pain study to investigate the pain experiences in transmen, and the impact of body image on pain in both ciswomen and transmen, the proposed research

疼痛是一种生物心理社会体验，但大多数研究仅集中在生物学领域，不能令人满意地解释疼痛体验。像疼痛一样，身体意象，一个人对其身体的大小、形状和特征的主观体验，是由生物学、心理学和社会文化构成的;因此，在多种疾病慢性疼痛疾病中报告了身体意象的紊乱。尽管存在这种联系，但身体意象与慢性疼痛之间的关系尚未得到理解。Moayedi教授提出的研究将加深我们对疼痛和身体意象交叉点的理解，并确定新的治疗靶点。通过解决两个研究主题。第一个主题将使用改变个体身体形状和大小的视觉错觉（例如，手指伸展错觉）来确定身体意象和疼痛体验之间的关系。该主题包括三个目标，即（1）确定与手指伸展错觉因果相关的脑区;（2）确定通过视觉错觉对身体意象的改变是否会改变对疼痛实验模型的敏感性;以及（3）因果确定哪些与身体意象相关的脑区影响对疼痛实验模型的敏感性。这将为与身体形象障碍相关的慢性疼痛确定潜在的新治疗靶点。主题2将确定手术后疼痛和身体形象变化的关系。本课题包括三个目标：（3）探索跨性别和顺性别女性的疼痛体验;（2）确定BPD与疼痛之间的关系;（3）BPD与疼痛关系的混合方法分析。本课题将结合定性访谈和定量方法，包括行为，心理物理和神经影像学方法，调查接受预防性乳房切除术的ciswomen和接受顶部手术的transmen的疼痛体验。作为第一个研究跨性别者疼痛体验的疼痛研究，以及身体意象对跨性别者和跨性别者疼痛的影响，