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Development and evaluation of a recombinant porcine adenovirus vaccine for post-exposure protection against Ebolavirus

Development and evaluation of a recombinant porcine adenovirus vaccine for post-exposure protection against Ebolavirus
用于埃博拉病毒暴露后保护的重组猪腺病毒疫苗的开发和评估
批准号：
206242
负责人：
Wong Gary C
金额：
$7.65万
依托单位：
University of Manitoba
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-10-01 至 2012-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=206242&lang=en
关键词：
Adaptive Immune Response Animal Models Ebolavirus Human Innate Level Iv Biocontainment Porcine Adenovirus Post-Exposure Protection Pre-Existing Immunity Recombinant Viruses Reverse Genetics Vaccine Design

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中文摘要
翻译
埃博拉病毒(EBOV)自发现以来造成了毁灭性的疾病，主要是在非洲，死亡率高达90%。由于经常检测到自然的人类暴发及其作为生物免疫的适宜性，它也引起了越来越多的全球关注。
英文摘要
Ebolavirus (EBOV) has caused devastating disease since its discovery, primarily in Africa with a death rate reaching up to 90%. It has also drawn increasing global attention due to frequent detection of natural human outbreaks and its suitability as a bi
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Structural characterization and optimization of ZMapp, an antibody cocktail efficacious against Ebola virus in nonhuman primates
Persistent infection and restimulation of Ebolavirus from dormancy in African fruit bats
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