Experimental and theoretical study of hydrodynamics of solid particle transport in small scale

小尺度固体颗粒输运的流体动力学实验与理论研究

• 批准号: RGPIN-2017-05272
• 负责人: Ahmadi, Ali
• 金额: $ 1.68万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752698
• 关键词: Experimental; theoretical; study; hydrodynamics; solid

The manipulation of solid particles in small scales has numerous applications including blood cell counting in hematology labs, fabrication of organs for implants and drug discovery, removal of bacteria from drinking water and monitoring particulate matter concentrations in air pollution. The efficiency of many of these applications strongly depends on the interaction of the particles with the surrounding fluid. The characterization of these interactions, however, becomes more challenging due to the decreased length and time scales in these miniaturized technologies.The proposed research program will focus on the theoretical and experimental aspects of the solid particle transport in rapidly changing small scale flows with direct application in the field of bio-printing. Bio-printing technologies have emerged to address the growing need for developing living tissue constructs that mimic the behaviour of the human body, and can be used for drug development or fabrication of functioning organs. As a new generation of bio-printers, inkjet printers have been utilized for controlled dispensing of living cells and biomaterials into specific patterns designed by computers. However, current inkjet bio-printers lack consistency, and face other problems including frequent nozzle clogging. The proposed program will fundamentally address the above mentioned challenges through the study of cell transport within the inkjet nozzles and microfluidic channels. In particular, a high speed imaging setup and numerical model will be developed to characterize the performance of inkjet cell printing systems. To increase the inkjet cell printing reliability, the use of viscoelastic bio-inks will be explored; the effects of rheological manipulation of bio-inks on the cell printing consistency will be studied. The fundamental knowledge of this novel research program can be applied in the development of technologies for handling solid particles in the small scale. These technologies will strengthen Canada's position as a leading country in advanced manufacturing and biotechnology fields. The HQP that will be trained in this program will be well suited to join the growing job market of these respective industrial fields.

在小尺度上操纵固体颗粒有许多应用，包括血液学实验室的血细胞计数，用于植入和药物发现的器官制造，从饮用水中去除细菌和监测空气污染中的颗粒物浓度。这些应用的效率很大程度上取决于颗粒与周围流体的相互作用。然而，由于这些小型化技术的长度和时间尺度缩短，这些相互作用的表征变得更具挑战性。拟建的研究项目将侧重于快速变化的小尺度流动中固体颗粒输运的理论和实验方面，并直接应用于生物打印领域。生物打印技术的出现是为了满足人们对模拟人体行为的活体组织结构的日益增长的需求，并可用于药物开发或功能器官的制造。作为新一代的生物打印机，喷墨打印机已被用于将活细胞和生物材料按计算机设计的特定图案进行控制分配。然而，目前的喷墨生物打印机缺乏一致性，并面临其他问题，包括频繁的喷嘴堵塞。该计划将通过研究喷墨喷嘴和微流体通道内的细胞运输，从根本上解决上述挑战。特别是，高速成像设置和数值模型将开发表征喷墨细胞打印系统的性能。为了提高喷墨细胞打印的可靠性，将探索粘弹性生物墨水的使用；研究了生物墨水的流变操纵对细胞打印一致性的影响。这个新研究项目的基础知识可以应用于小尺度固体颗粒处理技术的发展。这些技术将加强加拿大在先进制造业和生物技术领域的领先地位。将在该计划中接受培训的HQP将非常适合加入这些各自工业领域不断增长的就业市场。