Investigating the relationship between epigenetic regulators and molecular characteristics at single cell resolution in breast and ovarian cancer genomes.

研究乳腺癌和卵巢癌基因组中单细胞分辨率的表观遗传调节因子与分子特征之间的关系。

• 批准号: 486029
• 负责人: Liu Yi Fei
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486029&lang=en
• 关键词: Breast Cancer; Clonal Dynamics; Drug Resistance; Epigenetics; Genomic Instability; Ovarian Cancer; Patient-Derived Xenograft; Pooled Crispr Screen; Single Cell Transcriptomics; Tumour Heterogeneity

Advanced breast cancer and ovarian cancer are deadly diseases with limited treatment options, in part due to the variability between and within patients on the genetic level. This variability is masked by bulk tissue analysis which makes it difficult to o

晚期乳腺癌和卵巢癌是治疗选择有限的致命疾病，部分原因是患者之间和患者内部在遗传水平上的变异性。这种变异性被大量组织分析所掩盖，这使得难以确定是否存在这种变异性。