Neuromechanical mechanisms of human dynamic stability

人体动态稳定性的神经力学机制

基本信息

  • 批准号:
    RGPIN-2016-06005
  • 负责人:
  • 金额:
    $ 3.64万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The high incidence of falls and fall-related injuries among Canadians over the age of 65 is a key public health issue. The most current data indicates that this cohort represents approximately 15% of the Canadian population, yet it accounts for 51% of all unintentional fall cases requiring hospitalisation and totals 46% of health care costs for falls. As a result, the direct and indirect healthcare costs have been estimated at over 2 billion and 6 billion Canadian dollars, respectively. Despite population-based work that has revealed numerous factors that are predictive of falls, there has been little change in the population standardised rate of fall-related hospitalisation and injury among older adults. Effective balance control is the result of a complex relationship between proactive (to avoid instability) and reactive (to respond to instability) control processes that are bound by the neural (sensory) and mechanical (musculoskeletal) systems. Notwithstanding considerable clinical research focusing on balance control and falls among older adults, there is a scarcity of basic science research investigating the mechanisms of whole-body stability control. The proposed work will generate novel insights into human stability control and dyscontrol through three research themes that iteratively narrow in focus, moving from (a) a characterisation of whole body dynamic stability control, to (b) experimental manipulation of neuromechanical system properties, to (c) modelling individual-limb and joint-level contributions to dynamic stability.This work will utilise a combination of complementary biomechanical approaches to examine human dynamic stability across a range of activities of daily living. While many previous studies have examined proactive and reactive stability control in isolation, the present work will seek to examine the interaction between proactive and reactive control to determine if challenges in reactive control can be offset by improved proactive control. Such an outcome would support the use of perturbation-based training programs, which seek to improve proactive control through exposure to novel bouts of instability. This work will also seek to quantify the extent to which instability results from alterations to the neural and mechanical systems, given that these systems are directly influenced by growth, ageing and injury processes. Outcomes from this line of work will importantly inform the development of technological interventions seeking to offset neuromechanical deficits. Lastly, understanding individual limb and joint level contributions to dynamic stability provides a specific target to facilitate the development of more effective medical and technological fall prevention interventions. This line of study provides a framework for the training of nine undergraduate and graduate students within this funding period.
65岁以上加拿大人的高福尔斯和跌倒相关伤害发生率是一个关键的公共卫生问题。最新数据表明,该队列约占加拿大人口的15%,但占所有需要住院治疗的意外跌倒病例的51%,占福尔斯医疗保健费用的46%。因此,直接和间接的保健费用估计分别超过20亿和60亿加元。尽管基于人群的研究揭示了许多预测福尔斯的因素,但老年人中与跌倒相关的住院和受伤的人群标准化率几乎没有变化。有效的平衡控制是由神经(感觉)和机械(肌肉骨骼)系统约束的主动(避免不稳定)和反应(对不稳定做出反应)控制过程之间复杂关系的结果。尽管有相当多的临床研究集中在老年人的平衡控制和福尔斯,有一个缺乏基础科学研究调查全身稳定控制的机制。拟议的工作将通过三个研究主题产生对人类稳定性控制和失控的新见解,这些研究主题反复缩小焦点,从(a)全身动态稳定性控制的表征,到(B)神经机械系统特性的实验操作,至(c)为个别肢体及关节制作模型─水平的贡献动态稳定性。这项工作将利用互补的生物力学方法的组合,以检查人类的动态稳定性在一系列的日常生活活动。虽然许多以前的研究已经研究了主动和被动的稳定性控制隔离,目前的工作将寻求研究主动和被动控制之间的相互作用,以确定是否可以通过改进主动控制来抵消被动控制的挑战。这样的结果将支持使用扰动为基础的培训计划,寻求通过暴露于新的不稳定性发作,以提高主动控制。这项工作还将试图量化神经和机械系统的变化导致的不稳定程度,因为这些系统直接受到生长,衰老和损伤过程的影响。这项工作的成果将为寻求抵消神经力学缺陷的技术干预的发展提供重要信息。最后,了解个体肢体和关节水平对动态稳定性的贡献提供了一个具体的目标,以促进更有效的医疗和技术跌倒预防干预措施的发展。这一研究方向为在此资助期内培训9名本科生和研究生提供了一个框架。

项目成果

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Singer, Jonathan其他文献

Compassion Satisfaction to Combat Work-Related Burnout, Vicarious Trauma, and Secondary Traumatic Stress
  • DOI:
    10.1177/0886260518799502
  • 发表时间:
    2021-05-01
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Cummings, Caroline;Singer, Jonathan;Benuto, Lorraine T.
  • 通讯作者:
    Benuto, Lorraine T.
Contemporary trends in PGD incidence, outcomes, and therapies.
  • DOI:
    10.1016/j.healun.2022.08.013
  • 发表时间:
    2022-12
  • 期刊:
  • 影响因子:
    8.9
  • 作者:
    Cantu, Edward;Diamond, Joshua M.;Cevasco, Marisa;Suzuki, Yoshi;Crespo, Maria;Clausen, Emily;Dallara, Laura;Ramon, Christian, V;Harmon, Michael T.;Bermudez, Christian;Benvenuto, Luke;Anderson, Michaela;Wille, Keith M.;Weinacker, Ann;Dhillon, Gundeep S.;Orens, Jonathan;Shah, Pali;Merlo, Christian;Lama, Vibha;McDyer, John;Snyder, Laurie;Palmer, Scott;Hartwig, Matt;Hage, Chadi A.;Singer, Jonathan;Calfee, Carolyn;Kukreja, Jasleen;Greenland, John R.;Ware, Lorraine B.;Localio, Russel;Hsu, Jesse;Gallop, Robert;Christie, Jason D.
  • 通讯作者:
    Christie, Jason D.
Assessment of Oncology Advanced Practice Professional Willingness to Participate in Medical Aid in Dying.
  • DOI:
    10.1001/jamanetworkopen.2022.39068
  • 发表时间:
    2022-10-03
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Singer, Jonathan;Daum, Courtney;Shen, Megan J.;Zecha, Gabrielle;Kaplan, Louise;Plakovic, Kathy;Blazey, Meagan;Arnold, Molly;Silko, Barbara;Baker, Kelsey;Loggers, Elizabeth T.
  • 通讯作者:
    Loggers, Elizabeth T.
Relationship of cue-induced urinary urges to nocturia in women ages 18 to 40 years
  • DOI:
    10.1002/nau.23996
  • 发表时间:
    2019-06-01
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Singer, Jonathan;O'Connell, Kathleen A.
  • 通讯作者:
    O'Connell, Kathleen A.
Adaptive Simultaneous Topography and Broadband Nanomechanical Mapping of Heterogeneous Materials on Atomic Force Microscope
原子力显微镜上异质材料的自适应同步形貌和宽带纳米力学测绘
  • DOI:
    10.1109/tnano.2020.3010737
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Li, Tianwei;Zou, Qingze;Ma, Tianxing;Singer, Jonathan;Su, Chanmin
  • 通讯作者:
    Su, Chanmin

Singer, Jonathan的其他文献

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{{ truncateString('Singer, Jonathan', 18)}}的其他基金

Neuromechanical mechanisms of human dynamic stability
人体动态稳定性的神经力学机制
  • 批准号:
    RGPIN-2016-06005
  • 财政年份:
    2021
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Neuromechanical mechanisms of human dynamic stability
人体动态稳定性的神经力学机制
  • 批准号:
    RGPIN-2016-06005
  • 财政年份:
    2019
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Neuromechanical mechanisms of human dynamic stability
人体动态稳定性的神经力学机制
  • 批准号:
    RGPIN-2016-06005
  • 财政年份:
    2018
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Neuromechanical mechanisms of human dynamic stability
人体动态稳定性的神经力学机制
  • 批准号:
    RGPIN-2016-06005
  • 财政年份:
    2017
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Neuromechanical mechanisms of human dynamic stability
人体动态稳定性的神经力学机制
  • 批准号:
    RGPIN-2016-06005
  • 财政年份:
    2016
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Discovery Grants Program - Individual
Development of a Three-Dimensional Hinge System for Functional Knee Bracing
用于功能性膝关节支撑的三维铰链系统的开发
  • 批准号:
    319620-2005
  • 财政年份:
    2007
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Development of a Three-Dimensional Hinge System for Functional Knee Bracing
用于功能性膝关节支撑的三维铰链系统的开发
  • 批准号:
    319620-2005
  • 财政年份:
    2006
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Development of a Three-Dimensional Hinge System for Functional Knee Bracing
用于功能性膝关节支撑的三维铰链系统的开发
  • 批准号:
    319620-2005
  • 财政年份:
    2005
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Knee brace migration: determining the effects on the biomechanics of the lower limb during locomotion
护膝迁移:确定运动过程中对下肢生物力学的影响
  • 批准号:
    303502-2004
  • 财政年份:
    2004
  • 资助金额:
    $ 3.64万
  • 项目类别:
    Postgraduate Scholarships - Master's

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