Smart Capsule for non-invasive targeted sampling and delivery in the gut

用于肠道内非侵入性靶向采样和输送的智能胶囊

• 批准号: 571961-2022
• 负责人: Diller, EricED
• 金额: $ 9.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=759553
• 关键词: Smart; Capsule; non; invasive; targeted

We have developed a prototype magnetically-actuated capsule which can take samples wirelessly on demand from within the gastrointestinal (GI) tract. This capsule has a sample chamber and is activated wirelessly using a safe low-strength magnetic field. The operation is simpler than other robotic capsule endoscopes and does not rely on complex control systems or mechanisms but instead has a simple operation using a permanent magnet outside the body to activate the capsule. Following ingestion, the capsule position is tracked and once it reaches the location of interest within the small intestine, it is briefly opened using the magnetic field to collect a sample. After the field is removed, the capsule naturally closes and seals tightly, to be excreted for collection and sample analysis.We have shown that this capsule has robust sealing and reliable sampling activation, which we have tested in both laboratory and in-vivo field conditions. In initial animal trials, we have shown the device can be wirelessly activated within the stomach of live pigs. In this one-year I2I Phase I project, we aim to build on these discoveries to address two key challenges to the successful commercialization of our device. 1) We will refine our protocol and conduct two sets of live dog trials (each with 3 dogs) to prove the capsule can be used to sample/delivery anywhere within the GI tract. 2) Developing Next Generation Capsule with Localization Capability. For many use cases, the location of the capsule must be known prior to activation. While medical imaging (ultrasound, X-Ray fluoroscopy) can observe the capsule, we have developed a prototype magnetic localization method which takes advantage of the magnets already integrated into the capsule. The patient would wear a vest of magnetic sensors which will be used to calculate the position of the capsule within the body to an accuracy of less than 2 cm.

我们已经开发了一种磁力驱动胶囊的原型，它可以在胃肠道内按需无线采集样本。这种胶囊有一个样品室，并使用安全的低强度磁场以无线方式激活。这种操作比其他机器人胶囊内窥镜更简单，不依赖复杂的控制系统或机制，而是使用体外的永久磁铁来激活胶囊的简单操作。摄取后，跟踪胶囊的位置，一旦胶囊到达小肠内的感兴趣位置，就利用磁场短暂打开以收集样本。在移场后，胶囊自然关闭并密封，然后排出进行收集和样品分析。我们已经证明，这种胶囊具有坚固的密封性和可靠的取样激活，我们在实验室和活体野外条件下进行了测试。在最初的动物试验中，我们已经证明该设备可以在生猪的胃内无线激活。在这个为期一年的I2I第一阶段项目中，我们的目标是在这些发现的基础上，解决我们设备成功商业化的两个关键挑战。1)我们将完善我们的方案，并进行两组活狗试验(每组3只狗)，以证明该胶囊可用于胃肠道内任何地方的采样/递送。2)开发具有本地化能力的下一代太空舱。对于许多使用情况，在激活之前必须知道胶囊的位置。虽然医学成像(超声波、X射线透视)可以观察胶囊，但我们已经开发了一种原型磁定位方法，该方法利用已经集成到胶囊中的磁铁。患者将穿上磁性传感器背心，这些传感器将用于计算胶囊在体内的位置，精确度低于2厘米。