Evaluation of Novel Spine Musculoskeletal Biomechanics in Stability Control

新型脊柱肌肉骨骼生物力学在稳定性控制中的评价

• 批准号: RGPIN-2017-04037
• 负责人: Driscoll, Mark
• 金额: $ 3.35万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760164
• 关键词: Evaluation; Novel; Spine; Musculoskeletal; Biomechanics

As you read this proposal, please take a second to ponder how you are able to sit without having your spine collapse under the load of your upper body. If you are lucky, you have spinal stability and are free of discomfort. Unfortunately, for many, a form of collapse or mechanical failure is present. Understanding the mechanisms that contribute to spinal stability, or lack thereof, is the global theme of the proposed research program. Spinal disorders and associated back pain currently represent an epidemic hindering productivity and creating a massive economic burden to developed nations such as Canada. The presentation of a spinal disorder, mechanically, represents a flawed stability mechanism. This research program will leverage cross-disciplinary platforms and collaborations while studying spine biomechanics to generate and validate novel interpretations of spine stability. For the first time in this field, this research program will objectively explore the synergistic role of the abdominal cavity and paraspinal muscle compartment compressibility in spinal stability and, consequently, as a potential mechanism of spinal instability and subsequent disorders. It is hypothesized that the inclusion of the compressibility of pressurized abdominal and paraspinal compartments will alleviate the unrealistic tensional demands calculated for paraspinal muscles when utilizing conventional biomechanical interpretations of the spine. It is further hypothesized that the tensional envelopes, such as the abdominal ring surrounding these compartments, also play a role in stability and any offset in tensional capacities will introduce instability and compensatory patterns. The research program leverages prior expertise in spine biomechanics, high-performance computers, patient based physiological 3D models, and custom programed finite element modeling. Furthermore, the research program will train several HQPs (3 PhD, 3 MEng, and 3 BEng) on engineering computer programing, image processing, control, and stress analyses while submitting them to cross-disciplinary clinical and physiological theories and feeding the fast growing demand of biomedical engineers in the medical device market in Canada. Moreover, short and long term results are expected to have a broad impact by altering diagnostic and treatment methods related to spine instability.

当你阅读这份建议时，请花一点时间思考一下，你是如何坐着的，而不会让你的脊椎在你上半身的负荷下崩溃。 如果你幸运的话，你有脊柱稳定性，没有不适。不幸的是，对于许多人来说，存在某种形式的崩溃或机械故障。了解有助于脊柱稳定性的机制，或缺乏，是拟议的研究计划的全球主题。脊柱疾病和相关的背痛目前代表了一种流行病，阻碍了生产力，并给加拿大等发达国家造成了巨大的经济负担。脊柱疾病的表现，从机械上讲，代表了一种有缺陷的稳定机制。该研究计划将利用跨学科平台和合作，同时研究脊柱生物力学，以产生和验证脊柱稳定性的新解释。在这一领域的第一次，这项研究计划将客观地探讨腹腔和椎旁肌间室压缩性在脊柱稳定性中的协同作用，因此，作为脊柱不稳定和后续疾病的潜在机制。据推测，包括加压腹部和椎旁室的压缩性将减轻不切实际的张力需求计算的椎旁肌肉时，利用传统的生物力学解释的脊柱。 进一步假设，张力包层，例如围绕这些隔室的腹环，也在稳定性中起作用，并且张力能力的任何偏移将引入不稳定性和补偿模式。该研究计划利用了脊柱生物力学，高性能计算机，基于患者的生理3D模型和自定义编程有限元建模方面的专业知识。 此外，该研究计划将培训几名HQP（3名博士，3名MEng和3名BEng）工程计算机编程，图像处理，控制和应力分析，同时将其提交给跨学科的临床和生理理论，并满足加拿大医疗器械市场对生物医学工程师快速增长的需求。 此外，通过改变与脊柱不稳定相关的诊断和治疗方法，预计短期和长期结果将产生广泛的影响。