An innovative minimally invasive modular right ventricular assist device

本项目的总体目标是设计、优化和测试一种创新的新型心脏泵（右心室ModulHeart）治疗右心衰的安全性/有效性。右心衰是慢性肺和左心疾病的常见并发症，导致生活质量下降，患者死亡率和发病率增加，并造成重大的社会和经济负担。目前还没有医疗设备或药物专门用于右心衰的长期门诊管理。通过我们与Puzzle医疗设备公司（PMD）的合作，我们将设计、开发和测试一种新型的长期血管内右室辅助装置。方法。基于PMD在左心室ModulHeart设计方面的经验，我们将设计、开发和测试第一个长期血管内右心室辅助装置。该提案围绕五个强大的互补目标进行阐述：目标1：设计新的右心室模块心脏血管内推进器；目标2：优化微磁耦合设计，实现右心室支持；目标3：优化右室模块心脏的肺植入；目的#4：体外评估其性能和可靠性；目标5：在体外证明其血液相容性。预期结果显著性。右心室模块心脏将代表医疗设备发展的技术突破，并将打破右心衰的自然史。这一转化项目将对加拿大人的健康、模拟加拿大医疗器械行业和培养高素质人才产生重大影响。

The overall objective of this proposed project is to design, optimize and test the safety/efficacy of an innovative novel cardiac pump (right ventricular ModulHeart) for the treatment of right heart failure.BACKGROUND/RATIONALE. Right heart failure is a common complication of chronic lung and left heart disease leading to decreased quality of life, increased patient mortality and morbidity, and significant societal and economic burden. There are currently no medical devices or drugs dedicated to long-term ambulatory management of right heart failure. Through our collaboration with Puzzle Medical Devices Inc. (PMD), we will design, develop, and test a novel long-term endovascular right ventricular assist device. METHODS. Building on PMD's experience with the design of a left ventricular ModulHeart, we will design, develop and test the first long-term endovascular right ventricular assist device. The proposal is articulated around five strong complementary aims: Aim#1: Design the new endovascular propeller of the right ventricular ModulHeart; Aim#2: Optimize the design of the micro-magnetic coupling to enable right ventricular support; Aim#3: Optimize the pulmonary implantation of the right ventricular ModulHeart; Aim#4: In vitro evaluate its performance and reliability; and Aim#5: In vitro demonstrate its hemocompatibility.EXPECTED OUTCOMES SIGNIFICANCE. The right ventricular ModulHeart will represent a technological breakthrough in the development of medical devices and will disrupt the natural history of right heart failure. This translational project will lead to significant impacts on the health of Canadians, on simulating the Canadian medical device industry and on the training of Highly Qualified Personnel.