An innovative minimally invasive modular right ventricular assist device

创新的微创模块化右心室辅助装置

• 批准号: 571041-2021
• 负责人: KADEM, LyesL
• 金额: $ 13.34万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760533
• 关键词: innovative; minimally; invasive; modular; right

The overall objective of this proposed project is to design, optimize and test the safety/efficacy of an innovative novel cardiac pump (right ventricular ModulHeart) for the treatment of right heart failure.BACKGROUND/RATIONALE. Right heart failure is a common complication of chronic lung and left heart disease leading to decreased quality of life, increased patient mortality and morbidity, and significant societal and economic burden. There are currently no medical devices or drugs dedicated to long-term ambulatory management of right heart failure. Through our collaboration with Puzzle Medical Devices Inc. (PMD), we will design, develop, and test a novel long-term endovascular right ventricular assist device. METHODS. Building on PMD's experience with the design of a left ventricular ModulHeart, we will design, develop and test the first long-term endovascular right ventricular assist device. The proposal is articulated around five strong complementary aims: Aim#1: Design the new endovascular propeller of the right ventricular ModulHeart; Aim#2: Optimize the design of the micro-magnetic coupling to enable right ventricular support; Aim#3: Optimize the pulmonary implantation of the right ventricular ModulHeart; Aim#4: In vitro evaluate its performance and reliability; and Aim#5: In vitro demonstrate its hemocompatibility.EXPECTED OUTCOMES SIGNIFICANCE. The right ventricular ModulHeart will represent a technological breakthrough in the development of medical devices and will disrupt the natural history of right heart failure. This translational project will lead to significant impacts on the health of Canadians, on simulating the Canadian medical device industry and on the training of Highly Qualified Personnel.

本拟议项目的总体目标是设计、优化和测试用于治疗右心衰竭的创新新型心脏泵（右心室ModulHeart）的安全性/有效性。背景/依据。右心衰竭是慢性肺和左心疾病的常见并发症，导致生活质量下降、患者死亡率和发病率增加以及显著的社会和经济负担。目前还没有专门用于右心衰竭长期非卧床管理的医疗器械或药物。通过与Puzzle Medical Devices Inc.的合作，(PMD)我们将设计、开发和测试一种新型的长期血管内右心室辅助装置。方法.基于PMD在左心室ModulHeart设计方面的经验，我们将设计、开发和测试第一个长期血管内右心室辅助装置。该提案围绕五个强有力的互补目标进行阐述：目标1：设计右心室ModulHeart的新血管内推进器;目标2：优化微磁耦合的设计，以实现右心室支持;目标3：优化右心室ModulHeart的肺部植入;目标4：体外评价其性能和可靠性;目标5：体外试验证明其血液相容性。预期结果显著性。右心室ModulHeart将代表医疗设备开发的技术突破，并将破坏右心衰竭的自然史。该翻译项目将对加拿大人的健康，模拟加拿大医疗器械行业和高素质人才的培训产生重大影响。