Knifeless Limb Lengthening: Critical Advancement of an Innovative Therapy

无刀肢体延长：创新疗法的关键进展

• 批准号: 10899204
• 负责人: Matthew A Halanski
• 金额: $ 18.07万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10899204
• 关键词: Ablation; Acceleration; Advanced Development; Anatomy; Biomedical Engineering; Bone Growth; Bone Surface; Brain; Cardiac; Child; Child Care; Childhood; Clinical; Complication; Data; Deformity; Detection; Dose; Drug Targeting; Ensure; Evaluation; Excision; Fiber; Focused Ultrasound; Fracture; Goals; Growth; Growth Disorders; Hospitalization; Individual; Injury; Innovative Therapy; Kidney; Limb structure; Liver; Malignant neoplasm of liver; Measurement; Measures; Mediating; Methods; Microscopic; Modality; Molecular Analysis; Molecular Biology; Morbidity - disease rate; Musculoskeletal; Nerve; Nerve Crush; Nerve Fibers; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Oryctolagus cuniculus; Patients; Periosteum; Physiologic pulse; Precision therapeutics; Procedures; Prostate; Proteolysis; Quality of life; Rehabilitation therapy; Soft Tissue Injuries; Somatotropin; System; Technology; Therapeutic; Thrombus; Tissues; Transducers; Ultrasonic Therapy; Ultrasonics; Ultrasonography; Work; bone; healing; imaging capabilities; improved; injured; long bone; minimally invasive; new technology; response; skeletal; soft tissue; stem cell therapy; success; ultrasound

PROJECT SUMMARY/ABSTRACT Over 40,000 children in the US are hospitalized for musculoskeletal deformities each year. Abnormal and often diminished skeletal growth is the root cause of many of these conditions. For years, periosteal resection has been shown to accelerate longitudinal bone growth. Previous attempts to surgically exploit this phenomenon as a growth accelerating therapeutic modality have produced variable results that have not justified the procedures’ surgical morbidity and has been a major barrier to widespread clinical use. Recently, we have developed technology capable of performing these procedures non-invasively. However, the current technology lacks the necessary targeting and imaging capabilities to measure and ensure proper energy delivery at the bone surface. Furthermore, the exact portion of the periosteum that must be injured to accelerate growth is unclear. Thus, in the first aim we will determine the component of the periosteum injured during open surgical periosteal resection responsible for physeal growth acceleration and in the second aim we will integrate targeting capabilities into our system to allow precise placement of energy on the periosteum to minimize adjacent soft tissue injury. At the completion of the proposed work, we will have furthered our goal of developing a simple, non-invasive method to modulate skeletal growth.

项目总结/摘要 美国每年有超过40，000名儿童因肌肉骨骼畸形住院。不正常，经常 骨骼生长减少是许多这些病症的根本原因。多年来，骨膜切除术 加速纵向骨生长。以前尝试手术利用这种现象 作为一种加速生长的治疗方式，产生了各种各样的结果， 手术的外科发病率，并且已经成为广泛临床使用的主要障碍。最近我们 开发的技术能够进行这些程序非侵入性。但目前 技术缺乏必要的瞄准和成像能力来测量和确保适当的能量 在骨表面递送。此外，骨膜的确切部分，必须受伤， 加速增长尚不清楚。因此，在第一个目标中，我们将确定受损骨膜的组成部分 在开放手术骨膜切除负责骨骺生长加速，并在第二个目标，我们 将把瞄准能力整合到我们的系统中，使能量精确地放置在骨膜上， 尽量减少邻近软组织损伤。在完成拟议的工作后，我们将进一步实现我们的目标， 开发一种简单的非侵入性方法来调节骨骼生长。