Development of a triple haemodynamic monitoring system for mammalian physiology studies

用于哺乳动物生理学研究的三重血流动力学监测系统的开发

• 批准号: 565734-2021
• 负责人: West, ChristopherCR
• 金额: $ 11.15万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760885
• 关键词: Development; triple; haemodynamic; monitoring; system

In this proposal we will develop and test a new device to measure heart pressure, heart rate and blood flow from animals without the need for anesthesia. This device will be implanted into the abdomen or on the back of the animal and have leads that are surgically implanted into the heart. To develop this device a team of engineers will work with researchers from the UBC Faculty of Medicine. The devices will first be tested in a laboratory setting to optimize data collection protocols, power supply, and electronics as well as to ensure the devices can be remotely charged. Devices will then be surgically implanted into the animal and heart pressure, blood flow, and rate will be sampled beat-by-beat for 24hrs per day for up to 12 weeks. We also plan to develop a new device that can be used in conjunction with the telemetry system to enable us to assess the strength of the heart's contraction without the need for additional surgery. The development and testing of these devices, as well as the data we will obtain from within the same animals over time, will provide a significant advancement to the life science field as current approaches are not able to track all of these indices over time or assess the strength of the hearts contraction over time. The devices are expected to have applications across the life sciences, medicine, and industry.

在这项提案中，我们将开发和测试一种新的设备，在不需要麻醉的情况下测量动物的心率、心率和血流量。这种装置将被植入动物的腹部或背部，并具有通过手术植入心脏的导线。为了开发这种设备，一组工程师将与来自UBC医学院的研究人员合作。这些设备将首先在实验室环境中进行测试，以优化数据收集协议、电源和电子设备，并确保设备可以远程充电。然后，设备将被手术植入动物体内，并将在长达12周的时间里每天连续24小时逐个心跳地采集心脏压力、血流和心率。我们还计划开发一种新的设备，可以与遥测系统一起使用，使我们能够评估心脏收缩的强度，而不需要额外的手术。这些设备的开发和测试，以及我们将随着时间的推移从相同动物体内获得的数据，将为生命科学领域提供重大进展，因为目前的方法无法跟踪所有这些指数随时间的变化或评估心脏收缩的强度随时间的变化。预计这些设备将在生命科学、医学和工业中得到应用。