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Development and Optimization of Downstream Purification Process of LCY's Carotenoids Products

李长荣类胡萝卜素产品下游纯化工艺开发与优化

基本信息

批准号：
556138-2020
负责人：
Sheikhzadeh, MehdiM
金额：
$ 5.46万
依托单位：
Lambton College of Applied Arts and Technology
依托单位国家：
加拿大
项目类别：
Applied Research and Development Grants - Level 2
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=761510
关键词：
Development Optimization Downstream Purification Process

项目摘要

Carotenoids, vitamin A, beta carotene, lycopene, canthaxanthin, and astaxanthin, have many known health benefits and can be converted into nutraceuticals in the form of supplements and food additives. They can also be used as a natural colourant for the food industry, cosmetic industry, and pharmaceutical industry. These carotenoids can also be used as an additive in animal feed formulations.LCY Biosciences Inc. an LCY Chemical Corp. subsidiary, focuses on chemical production through bio-based raw materials and sustainable processes. In 2018, LCY acquired the former BioAmber plant in Sarnia, Ontario with intentions of restarting the production of bio-based succinic acid and also to begin the production of bio-based carotenoids using the LCY Biosciences proprietary biotechnology platform. LCY Biosciences' production of bio-based succinic acid is an established process, but the process of producing bio-based carotenoids is under development. LCY & Lambton College have built a positive partnership through a previous project that worked to optimize LCY's fermentation process. Building on this success, LCY's main objective of this project is to develop and optimize the downstream purification process for the named carotenoids products and establish the QA/QC procedures.The success of this project will be instrumental for LCY to move forward on their carotenoids production line and commercialization. The commercialization of this carotenoid product will not only economically benefit Canada through economic growth and job creation, but it will also environmentally benefit Canada by using agriculture biomass as feedstock instead of petrochemical sources and minimizing the chemical waste production through the fermentation process instead of chemical synthetic method to produce carotenoids.

类胡萝卜素、维生素A、β胡萝卜素、番茄红素、角黄素和虾青素有许多已知的健康益处，可以转化为补充剂和食品添加剂形式的营养食品。它们还可用作食品工业、化妆品工业和制药工业的天然着色剂。这些类胡萝卜素也可以用作动物饲料配方中的添加剂。LCY生物科学公司是LCY化学公司的子公司，专注于通过基于生物的原材料和可持续工艺生产化学产品。2018年，LCY收购了位于安大略省萨尼亚的前BioAmber工厂，意在重新启动生物基琥珀酸的生产，并开始使用LCY Biosciences专有生物技术平台生产生物基胡萝卜素。LCY生物科学公司生产生物基琥珀酸是一个成熟的工艺，但生产生物基类胡萝卜素的工艺正在开发中。LCY和兰伯顿学院通过之前致力于优化LCY发酵过程的项目，建立了积极的合作伙伴关系。在此基础上，本项目的主要目标是开发和优化命名类胡萝卜素产品的下游提纯工艺，并建立质量保证/质量控制程序。该项目的成功将有助于莱茵的类胡萝卜素生产线和商业化的发展。这种类胡萝卜素产品的商业化不仅将通过经济增长和创造就业机会为加拿大带来经济利益，而且还将使加拿大环境受益，因为它使用农业生物质作为原料而不是石化来源，并通过发酵过程而不是化学合成方法生产类胡萝卜素来最大限度地减少化学废物的产生。