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Development and Optimization of Downstream Purification Process of LCY's Carotenoids Products

李长荣类胡萝卜素产品下游纯化工艺开发与优化

基本信息

批准号：
556138-2020
负责人：
Sheikhzadeh, MehdiM
金额：
$ 5.46万
依托单位：
Lambton College of Applied Arts and Technology
依托单位国家：
加拿大
项目类别：
Applied Research and Development Grants - Level 2
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=761510
关键词：
Development Optimization Downstream Purification Process

项目摘要

Carotenoids, vitamin A, beta carotene, lycopene, canthaxanthin, and astaxanthin, have many known health benefits and can be converted into nutraceuticals in the form of supplements and food additives. They can also be used as a natural colourant for the food industry, cosmetic industry, and pharmaceutical industry. These carotenoids can also be used as an additive in animal feed formulations.LCY Biosciences Inc. an LCY Chemical Corp. subsidiary, focuses on chemical production through bio-based raw materials and sustainable processes. In 2018, LCY acquired the former BioAmber plant in Sarnia, Ontario with intentions of restarting the production of bio-based succinic acid and also to begin the production of bio-based carotenoids using the LCY Biosciences proprietary biotechnology platform. LCY Biosciences' production of bio-based succinic acid is an established process, but the process of producing bio-based carotenoids is under development. LCY & Lambton College have built a positive partnership through a previous project that worked to optimize LCY's fermentation process. Building on this success, LCY's main objective of this project is to develop and optimize the downstream purification process for the named carotenoids products and establish the QA/QC procedures.The success of this project will be instrumental for LCY to move forward on their carotenoids production line and commercialization. The commercialization of this carotenoid product will not only economically benefit Canada through economic growth and job creation, but it will also environmentally benefit Canada by using agriculture biomass as feedstock instead of petrochemical sources and minimizing the chemical waste production through the fermentation process instead of chemical synthetic method to produce carotenoids.

类胡萝卜素、维生素A、β -胡萝卜素、番茄红素、角黄素和虾青素有许多已知的健康益处，可以以补充剂和食品添加剂的形式转化为营养保健品。它们还可以用作食品工业、化妆品工业和制药工业的天然着色剂。这些类胡萝卜素也可用作动物饲料配方的添加剂。LCY Biosciences Inc.是LCY Chemical Corp.的子公司，专注于通过生物原料和可持续工艺进行化学生产。2018年，LCY收购了安大略省萨尼亚的前BioAmber工厂，意图重新启动生物基琥珀酸的生产，并开始使用LCY Biosciences专有的生物技术平台生产生物基类胡萝卜素。LCY Biosciences生产生物基琥珀酸是一个既定的工艺，但生产生物基类胡萝卜素的工艺还在开发中。LCY和兰姆顿学院通过之前的一个项目建立了积极的合作伙伴关系，该项目致力于优化LCY的发酵过程。在此成功的基础上，LCY项目的主要目标是开发和优化命名的类胡萝卜素产品的下游净化工艺，并建立QA/QC程序。该项目的成功将有助于LCY推进其类胡萝卜素生产线和商业化。这种类胡萝卜素产品的商业化不仅将通过经济增长和创造就业机会在经济上使加拿大受益，而且还将通过使用农业生物质作为原料而不是石化原料，并通过发酵过程而不是化学合成方法来生产类胡萝卜素，从而最大限度地减少化学废物的产生，从而使加拿大在环境上受益。