Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
基本信息
- 批准号:RGPIN-2018-06767
- 负责人:
- 金额:$ 2.4万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Bio-printing has emerged as one of the most influential applications of 3D printing, aiming to address the increased demand for living constructs with long term mechanical and biological stability suitable for transplantation, as well as improved drug discovery models. Existing 3D bio-printing technologies use electromechanical processes to deliver “inks” containing live cells, usually called bio-inks. Bio-inks are extremely sensitive to thermal and mechanical stress, thus existing bio-printing processes face the challenge of maintaining cell viability during the printing process. In this context, the long-term objective of my research is to address the ongoing demand for improved 3D bio-printing approaches, which are (i) compatible with both low and high viscosity bio-ink formulations, and (ii) capable to generate functional living constructs of biological relevant size with high resolution and speed. Towards this aim, we will develop, model, and validate novel bio-printing approaches that leverage laser-generated micro-jets to bio-print 3D living constructs. The specific aims are: (a) To develop a complete modeling framework for the physical mechanisms involved in laser printing of bio-inks. (b) To experimentally validate and optimize the performance of novel 3D laser bio-printing architectures by using model inks. (c) To validate optimized 3D laser bio-printing architectures for layer-by-layer printing of functional 3D living constructs. The proposed program can enable bio-printing processes that are compatible with a large variety of bio-ink formulations and offer enhanced post-printing cell viability. Importantly, it can eventually lead to the development of affordable, small-footprint bio-printing devices for tissue engineering applications. In the near future, those systems are expected to be heavily used for drug screening models, as compounds could be evaluated on bio-printed tissue before initiation of human trials.
生物打印已成为3D打印最具影响力的应用之一,旨在满足对适合移植的长期机械和生物稳定性的活体结构以及改进的药物发现模型的需求。现有的3D生物打印技术使用机电过程来提供含有活细胞的“墨水”,通常称为生物墨水。生物墨水对热和机械应力极其敏感,因此现有的生物打印工艺面临着在打印过程中保持细胞活力的挑战。在这种情况下,我的研究的长期目标是解决对改进的3D生物打印方法的持续需求,这些方法(i)与低粘度和高粘度生物墨水配方兼容,(ii)能够以高分辨率和速度生成生物相关尺寸的功能性活体结构。为了实现这一目标,我们将开发,建模和验证新的生物打印方法,利用激光产生的微射流来生物打印3D活体结构。具体目标是:(a)为生物油墨激光打印中涉及的物理机制开发一个完整的建模框架。(b)通过使用模型墨水,实验验证和优化新型3D激光生物打印架构的性能。 (c)验证优化的3D激光生物打印架构,用于逐层打印功能性3D活体结构。该计划可以实现与各种生物墨水配方兼容的生物打印过程,并提供增强的打印后细胞活力。重要的是,它最终可以导致开发负担得起的,小足迹的生物打印设备,用于组织工程应用。在不久的将来,这些系统预计将被大量用于药物筛选模型,因为化合物可以在人体试验开始之前在生物打印组织上进行评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Boutopoulos, Christos其他文献
Cell-specific optoporation with near-infrared ultrafast laser and functionalized gold nanoparticles
- DOI:
10.1039/c5nr05650k - 发表时间:
2015-01-01 - 期刊:
- 影响因子:6.7
- 作者:
Bergeron, Eric;Boutopoulos, Christos;Meunier, Michel - 通讯作者:
Meunier, Michel
Development and ex-vivo validation of 36G polyimide cannulas integrating a guiding miniaturized OCT probe for robotic assisted subretinal injections
- DOI:
10.1364/boe.448471 - 发表时间:
2022-02-01 - 期刊:
- 影响因子:3.4
- 作者:
Abid, Alexandre;Duval, Renaud;Boutopoulos, Christos - 通讯作者:
Boutopoulos, Christos
Drop-on-demand cell bioprinting via Laser Induced Side Transfer (LIST)
- DOI:
10.1038/s41598-020-66565-x - 发表时间:
2020-06-16 - 期刊:
- 影响因子:4.6
- 作者:
Orimi, Hamid Ebrahimi;Kolkooh, Sayadeh Sara Hosseini;Boutopoulos, Christos - 通讯作者:
Boutopoulos, Christos
Polymer/carbon nanotube composite patterns via laser induced forward transfer
- DOI:
10.1063/1.3299004 - 发表时间:
2010-01-25 - 期刊:
- 影响因子:4
- 作者:
Boutopoulos, Christos;Pandis, Christos;Zergioti, Ioanna - 通讯作者:
Zergioti, Ioanna
Laser-induced forward transfer of silver nanoparticle ink: time-resolved imaging of the jetting dynamics and correlation with the printing quality
- DOI:
10.1007/s10404-013-1248-z - 发表时间:
2014-03-01 - 期刊:
- 影响因子:2.8
- 作者:
Boutopoulos, Christos;Kalpyris, Ioannis;Zergioti, Ioanna - 通讯作者:
Zergioti, Ioanna
Boutopoulos, Christos的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Boutopoulos, Christos', 18)}}的其他基金
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2019
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
DGECR-2018-00014 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Launch Supplement
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
Galaxy Analytical Modeling
Evolution (GAME) and cosmological
hydrodynamic simulations.
- 批准号:
- 批准年份:2025
- 资助金额:10.0 万元
- 项目类别:省市级项目
相似海外基金
Research and Development of Numerical Methods of Multiphysics and Multiscale Modeling for Emerging Technology Applications and Designs
新兴技术应用和设计的多物理场和多尺度建模数值方法的研究和开发
- 批准号:
RGPIN-2018-05364 - 财政年份:2022
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization
创建用于生物医学应用的下一代抗菌混合复合材料:制造、多尺度建模和机械表征
- 批准号:
RGPIN-2019-05615 - 财政年份:2022
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Multiscale Multistage Ecological and Evolutionary Modeling with Applications to Social Insect Colonies
多尺度多阶段生态和进化模型及其在社会性昆虫群体中的应用
- 批准号:
2052820 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Standard Grant
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Research and Development of Numerical Methods of Multiphysics and Multiscale Modeling for Emerging Technology Applications and Designs
新兴技术应用和设计的多物理场和多尺度建模数值方法的研究和开发
- 批准号:
RGPIN-2018-05364 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization
创建用于生物医学应用的下一代抗菌混合复合材料:制造、多尺度建模和机械表征
- 批准号:
RGPIN-2019-05615 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Research and Development of Numerical Methods of Multiphysics and Multiscale Modeling for Emerging Technology Applications and Designs
新兴技术应用和设计的多物理场和多尺度建模数值方法的研究和开发
- 批准号:
RGPIN-2018-05364 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization
创建用于生物医学应用的下一代抗菌混合复合材料:制造、多尺度建模和机械表征
- 批准号:
RGPAS-2019-00127 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Creating the Next Generation of Antimicrobial Hybrid Composites for Biomedical Applications: Manufacturing, Multiscale Modeling, and Mechanical Characterization
创建用于生物医学应用的下一代抗菌混合复合材料:制造、多尺度建模和机械表征
- 批准号:
RGPIN-2019-05615 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Multiscale Modeling and Applications of Three-Dimensional (3D) Laser Bio-printing
三维(3D)激光生物打印的多尺度建模和应用
- 批准号:
RGPIN-2018-06767 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual