Networks underlying social cognition in the common marmoset (Callithrix jacchus) investigated with functional magnetic resonance imaging

通过功能磁共振成像研究普通狨猴（Callithrix jacchus）社会认知的网络

• 批准号: RGPIN-2022-04694
• 负责人: Everling, Stefan
• 金额: $ 2.84万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=764583
• 关键词: Networks; underlying; social; cognition; common

The New World common marmoset (Callithrix jacchus) is rapidly becoming popular as a powerful complement to canonical Old World primate (i.e., macaques) and rodent models (i.e., rats and mice) for preclinical modeling of the human brain in healthy and diseased states. The marmoset's fast sexual maturation, low inter-birth interval, and routinely observed chimeric twinning make it the leading candidate for transgenic primate models. The lissencephalic (smooth) marmoset cortex also offers the opportunity for laminar electrophysiological recordings and optical imaging. Owing to a well-developed frontal cortex, their prosocial behaviour, and the feasibility of creating transgenic marmosets, the marmoset holds tremendous promise as a nonhuman primate model for social cognition. The long-term goal of my NSERC funded research program is to advance our fundamental understanding of the neural basis of social cognition in primates. My short-term objectives for the next 5 years are to use ultra-high field fMRI at 9.4 Tesla in awake marmosets to: (1) Identify the marmoset mirror system using task-based fMRI (2) Identify the marmoset physical and social interaction analysis network using task-based fMRI (3) Use movie-driven fMRI to identify neural networks underling social cognition Our hypothesis is that social cognition networks in marmosets follow similar organization principles as in macaques and that marmosets possess dedicated brain circuits serving understanding of actions and social interactions. These studies will provide the foundation for invasive recording, manipulation, and inactivation techniques in marmosets. The data will also make substantial contributions to already existing neuroimaging data from humans and macaque monkeys that promises to transform cross-species comparative neuroscience.

新世界普通狨猴（Callithrix jacchus）作为典型的旧大陆灵长类动物（即猕猴）和啮齿动物模型（即大鼠和小鼠）的有力补充，正在迅速流行起来，用于健康和患病状态下的人类大脑临床前模型。狨猴性成熟快，生育间隔短，并经常观察到嵌合双胞胎，使其成为转基因灵长类动物模型的主要候选者。无脑绒猴皮层也为层流电生理记录和光学成像提供了机会。由于发育良好的额叶皮质，它们的亲社会行为，以及创造转基因狨猴的可行性，狨猴作为非人类灵长类动物的社会认知模型具有巨大的前景。我的国家科学研究委员会资助的研究项目的长期目标是推进我们对灵长类动物社会认知的神经基础的基本理解。我未来5年的短期目标是在清醒的狨猴身上使用9.4特斯拉的超高场功能磁共振成像：(1)使用任务型功能磁共振成像识别狨猴镜像系统(2)使用任务型功能磁共振成像识别狨猴身体和社会互动分析网络(3)使用电影驱动的功能磁共振成像识别社会认知的神经网络我们的假设是，狨猴的社会认知网络遵循与猕猴相似的组织原则，并且狨猴具有用于理解行为和社会互动的专用脑回路。这些研究将为侵入性记录、操作和灭活狨猴技术提供基础。这些数据也将对现有的人类和猕猴的神经成像数据做出重大贡献，这些数据有望改变跨物种比较神经科学。