Computational tools for Impedance Imaging

阻抗成像计算工具

• 批准号: RGPIN-2022-04927
• 负责人: Adler, Andy
• 金额: $ 4.01万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=765846
• 关键词: Computational; tools; Impedance; Imaging

Electrical Impedance Tomography (EIT) investigates the electrical properties of tissue with body-surface electrodes. The applicant is an internationally recognized expert in EIT image reconstruction and analysis algorithms. In the past grant period, contributions have been disseminated by editing of the main textbook and leading consensus projects on algorithms and data analysis, an open-source software tool which has become the most widely used in the field, in the scientific literature (47 journal papers), and supervising 16 graduate students, 4 PDFs and 60 undergraduate students. Software developed by the research team is a core component of three companies' products. This grant will focus on two specific EIT applications: non-invasive measurement of pulmonary arterial pressure (PAP) for monitoring of heart-failure; and sensitive measures of bronchoconstriction to monitor obstructive lung disease. These conditions affect very large populations, and early results are promising. Heart failure (HF) affects a large fraction of the elderly popultion, and occurs when the valves degrade or the heart becomes too weak to pump blood adequately. When the right heart compensates for HF, PAP increases, and the high blood pressure squeezes fluid into the airspaces leading tolung edema, congestion and shortness of breath. An exacerbation of heart failure requires admission to urgent care; however, the increases in PAP which lead to these exacerbations are detectable days or weeks before symptoms, and interventions during this window dramatically improve patient outcomes. Development will focus on recent work showing PAP can be measured non-invasively with EIT. HR-synchronized filtered data are reconstructed and the EIT signal in the lung region extracted. Two improvements to this algorithm will be researched: calcultion of millisecond-accuracy images, and error-tolerant algorithms. Diseases such as asthma and chronic obstructive lung disease, result from lung inflammation due to exposure to irritants and particularly smoke, and result in cough, mucus production and wheezing. With proper care and monitoring most patients can control symptoms and improve their quality of life. Monitoring of obstructive lung disease is inconvenient, and also gives only a global picture of the highly-heterogeneous lung. Recent work suggests that EIT can detect airflow limitation in a more sensitive way by analyzing the regional distribution of flow-volume parameters. Within this grant, we will research optimized electrode locations, robust 3D imaging, and regional flow-volume parameters. Results will be translated to Canadian partner companies. While working on specific technology applications, this grant will also further develop robust algorithms and computational tools useful to improve the accuracy and sensitivity of EIT, and make these contributions available through open-source software.

电阻抗断层成像(EIT)研究具有体表电极的组织的电特性。申请人是国际公认的EIT图像重建和分析算法专家。在过去的赠款期间，通过编辑主要教科书和领导关于算法和数据分析的协商一致项目，在科学文献(47篇期刊论文)中传播捐款，并指导16名研究生、4名PDF和60名本科生。算法和数据分析是该领域使用最广泛的开源软件工具。研究团队开发的软件是三家公司产品的核心组件。这笔赠款将集中在两个具体的EIT应用上：用于监测心力衰竭的非侵入性测量肺动脉压(PAP)；以及用于监测阻塞性肺疾病的敏感的支气管收缩措施。这些情况影响了非常大的人口，初步结果是有希望的。心力衰竭(HF)影响了很大一部分老年人，当瓣膜退化或心脏虚弱以至于无法充分泵血时就会发生。当右心代偿心衰时，PAP增加，高血压将液体挤压到空气中，导致肺水肿、充血和呼吸急促。心力衰竭的恶化需要接受紧急护理；然而，导致这些恶化的PAP增加在症状出现前几天或几周就可以检测到，这段时间内的干预措施极大地改善了患者的预后。开发的重点将放在最近的工作上，表明可以用EIT非侵入性地测量PAP。重建HR同步的滤波数据，提取肺部区域的EIT信号。将研究该算法的两个改进：毫秒精度图像的计算和容错算法。哮喘和慢性阻塞性肺病等疾病是由于暴露于刺激物，尤其是烟雾引起的肺部炎症，导致咳嗽、粘液产生和喘息。通过适当的护理和监测，大多数患者可以控制症状，提高他们的生活质量。对阻塞性肺病的监测很不方便，而且只给出了高度不同的肺的全球图景。最近的工作表明，EIT可以通过分析流量-体积参数的区域分布来更敏感地检测气流限制。在这笔赠款中，我们将研究优化的电极位置、稳健的3D成像和区域流量-体积参数。结果将被翻译给加拿大的合作伙伴公司。在致力于具体技术应用的同时，这笔赠款还将进一步开发强大的算法和计算工具，有助于提高EIT的准确性和敏感性，并通过开放源码软件提供这些贡献。