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The effect of HIV infection and anti-retroviral therapy on expression levels of the IL-27 cytokine and receptor subunits, and on the IL-27-induced signalling and downstream functions.

The effect of HIV infection and anti-retroviral therapy on expression levels of the IL-27 cytokine and receptor subunits, and on the IL-27-induced signalling and downstream functions.
HIV 感染和抗逆转录病毒治疗对 IL-27 细胞因子和受体亚基表达水平以及 IL-27 诱导的信号传导和下游功能的影响。
批准号：
197248
负责人：
Guzzo Christina R
金额：
$10.93万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-11-01 至 2012-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=197248&lang=en
关键词：
Anti-Viral Therapy Cell Signaling Cytokines Elisa Flow Cytometry Hiv Human Monocytes Inflammation Molecular Biology Quantitative Pcr

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英文摘要
This project aims to characterize how HIV affects normal cell-to-cell communication in the immune system. Recently, a novel cell communicating molecule, interleukin-27 (IL-27), was discovered to play a role in regulation of immune responses. IL-27 is rela
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