类皮肤无线呼吸监测集成器件研究

目前，针对柔性生物医疗电子器件的研究主要集中在利用材料和结构设计实现器件的可延展柔性化，研究对象多为分立器件，尚不能满足临床医学对高性能柔性监测器件的需求。因此，有必要发展高性能类皮肤集成器件的设计与制备方法，并深入探索其在临床医学上的应用。本项目提出的研究方案是将类皮肤传感器与基于裸芯片（未封装的集成电路芯片）的可延展柔性电路混合集成，从而得到高性能类皮肤集成器件。具体而言，本项目针对睡眠呼吸监测的临床需求，通过力电耦合分析发展类皮肤无线集成器件的设计方法与精准测量原理，结合微加工技术和3D打印技术发展类皮肤无线集成器件制备方法，分别利用疲劳测试实验方法与界面力学理论研究该集成器件在人体大变形环境下的失效机理与可靠性评估准则，最后将该集成器件用于临床实验以探索其在睡眠医学上的应用，建立睡眠呼吸监测算法，为发展高性能类皮肤集成医疗器件提供科学依据和技术指导。

Currently, most research of flexible biomedical devices is focused on the development of new materials and structures to achieve flexibility and stretchability, yet most devices are discrete which do not meet the clinical demand in integrated device with high performance. Therefore, it is important and necessary to develop design and fabrication strategies for skin-like integrated devices with high performance, and explore their potential in medical applications. Here, we propose to investigate in the skin-like integrated devices with high performance by combining skin-like sensors and stretchable circuits based on unpackaged dies, and then use them for the purpose of breath monitoring. Specifically, the design strategy of skin-like integrated device for breath monitoring will be investigated by combined analysis of mechanics and electrics, and the hybrid fabrication scheme will be developed by jointly using microelectronics and 3D printing technology. Then the failure mechanism and reliability assessment criterion of the device under circumstances of large deformation will be studied by fatigue testing and interface mechanics analysis before conducting clinical experiments in the sleep medical center and building the algorithms for sleeping-breathing monitoring, thus providing technology support and guidance for future research in skin-like and high-performance integrated biomedical devices.