Stable and low-resistance polydopamine methacrylamide-polyacrylamide hydrogel for brain-computer interface
Stable and low-resistance polydopamine methacrylamide-polyacrylamide hydrogel for brain-computer interface
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用于脑机接口的稳定低电阻聚多巴胺甲基丙烯酰胺-聚丙烯酰胺水凝胶
DOI：
10.1007/s40843-022-2145-3
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Xue Feng
中科院分区：
文献类型：
--
作者：
Lanlan Liu;Yafeng Liu;Ruitao Tang;Jun Ai;Yinji Ma;Ying Chen;Xue Feng
刚性金属电极与柔软人体皮肤之间的界面失效会导致脑-机接口设备的信号漂移和性能不稳定，影响脑电数据的精确采集。因此，期望实现用于脑机接口设备的鲁棒接口。本文研制了一种聚多巴胺甲基丙烯酰胺-聚丙烯酰胺（PDMA-PAAM）水凝胶。为了提高粘附性，将多巴胺引入到聚丙烯酰胺水凝胶中，通过多巴胺的氨基和邻苯二酚基团在有机-无机界面上建立共价和非共价相互作用。金属电极与人体皮肤之间可以形成牢固的附着和有效的模量转换体系，使PDMA-PAAM水凝胶与猪皮肤之间的剥离力达到22 N m-1。此外，PDMA-PAAM水凝胶的稳定导电性和在室温下超过60天的长期使用寿命分别通过添加氯化钠（NaCl）和甘油来实现。在这项工作中制造的PDMA-PAAM水凝胶膜集成到一个灵活的Au电极应用在脑-机接口。通过比较，采集到的脑电信号强度和波形与市售同类产品一致。显然，具有PDMA-PAAM水凝胶膜的柔性电极被证明能够实现更稳定和用户友好的界面。
Signal drift and performance instability of brain-computer interface devices induced by the interface failure between rigid metal electrodes and soft human skin hinder the precise data acquisition of electroencephalogram (EEG). Thus, it is desirable to achieve a robust interface for brain-computer interface devices. Here, a kind of polydopamine methacrylamide-polyacrylamide (PDMA-PAAM) hydrogel is developed. To improve the adhesion, dopamine is introduced into the polyacrylamide hydrogel, through the amino and catechol groups of dopamine in an organic-inorganic interface to build a covalent and non-covalent interaction. A strong attachment and an effective modulus transition system can be formed between the metal electrodes and human skin, so that the peeling force between the PDMA-PAAM hydrogel and the porcine skin can reach 22 N m−1. In addition, the stable conductivity and long-term operating life of the PDMA-PAAM hydrogel for more than 60 days at room temperature are achieved by adding sodium chloride (NaCl) and glycerol, respectively. The PDMA-PAAM hydrogel membrane fabricated in this work is integrated onto a flexible Au electrode applied in a brain-computer interface. In comparison, the collected EEG signal intensity and waveform are consistent with that of the commercial counterparts. And obviously, the flexible electrode with PDMA-PAAM hydrogel membrane is demonstrated to enable a more stable and user-friendly interface.
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影响因子：
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