化疗脑（Chemobrain）是指癌症患者化疗相关的认知功能损害。化疗延长了乳腺癌患者的生存期，但化疗脑却严重影响了其生活质量。最近大量的研究发现了乳腺癌化疗脑的特征及其可能的生物学机制，但迄今，乳腺癌化疗脑如何干预尚不清楚。有研究提示（Managing Cancer And Living Meaningful, CALM）是可用于癌症患者心理干预的有效方法，但CALM改善乳腺癌化疗脑的生物学机制也不明确。本研究以乳腺癌化疗脑患者为研究对象，对其 CALM干预前后分别进行认知功能测查、脑功能成像研究、事件相关电位（ERP）监测以及细胞因子水平，APOE、COMT基因多态性检测；探讨 CALM心理干预后乳腺癌化疗脑患者的认知功能、前额叶、海马等脑区功能连接，ERP中N400和P300成分，细胞因子水平及APOE、COMT基因表达多态性的改变；从而揭示乳腺癌化疗脑CALM心理干预的生物学机制。

Chemobrain refers to cancer patients experience with cognitive impairment related to chemotherapy.The survival time of patients with breast cancer are prolonged by chemotherapy, but their quality of life were seriously affected by chemobrain. Recently a lot of evidence have found that the characteristics of breast cancer chemobrain and its possible biological mechanisms, but how to intervention breast cancer chemobrain is unclear. More and more evidence from Psycho-Oncology research suggests(Managing Cancer And Living Meaningful, CALM ) is one of the important intervention methods that can be used for cancer patients psychological intervention, whether the CALM can improve the clinical features of breast cancer chemobrain patients,and what is the exact mechanism of CALM, all these are not clear now. In present research, We investigated breast cancer chemobrain patients who undergo CALM psychological intervention. They were assessed by cognitive neuropsychological test, function MRI, event related potential(ERP) research, the level of cytokines and APOE,COMT gene polymorphism before and after the intervention. To explore cognitive function change; N400 and P300 change in the ERP; the brain function connection change in the prefrontal cortex and hippocampus; the levels of cytokines and polymorphism of APOE and COMT in breast cancer chemobrain patients after CALM psychological intervention, and to revealed effect of CALM psychological intervention in breast cancer chemobrain patients and its biological mechanisms.