感染性疾病严重威胁人类的健康，这一状况随着临床耐药性的出现进一步恶化。在本项目中，我们将非天然氨基酸引入到来源于微生物、作用机制新颖、具有良好抗感染活性的天然产物---硫链丝菌素中，发展高效快速的结构衍生和大量制备的生物学方法。在丰富硫肽类家族结构多样性的前提下,利用这些分子作为化学探针开展抗感染的机制研究。

Nowadays, infectious diseases pose serious threats to public health and this situation is becoming worse due to the progressively emerging microbial resistance. In this project, we will insert unnatural amino acids into thiostrepton which shows the potent anti-infective activities with new or uncovered modes of action. We will develop highly effective, new biological approaches in recombinant microorganisms for structural diversity and their preparation in large scales by fermentation. We will use these thiostrepton analogues as chemical probes to explore mechanism of their anti-infective activities, based on the enrichment of diverse chemical entities.