磺酰胺或亚硫酰胺是一类具有光谱活性的药物化合物。广泛作为抗菌剂，利尿剂，抗惊厥药，和HIV蛋白酶抑制剂等。本课题主要涉及磺酰胺或亚硫酰胺化合物的合成方法学研究。近年来催化活化DMSO构建有机分子的反应已成为有机合成的研究热点之一。因此，从廉价的DMSO出发，以一级胺、二级胺、三级胺、酰胺为反应底物，通过筛选催化剂和氧化剂，来研究活化DMSO和S-N键的形成反应。合成一些特殊结构的苄胺、苯甲酰胺、苯丙胺等化合物，研究其S-N键的形成反应和分子内的环化反应，以拓展磺酰胺或亚硫酰胺化合物的合成路线和方法。研究邻氨基苯乙炔、邻氨基苯甲酸、邻氨基苄醇化合物与DMSO的偶联反应，提供简便方法合成一些难于制备的磺酰胺或亚硫酰胺化合物。利用上述催化DMSO构建磺酰胺或亚硫酰胺的反应技术，合成一些现有医药或农药分子，或进行结构修饰。这些研究成果可为医药和农药中间体的合成提供简洁路线，具有潜在的应用价值。

Sulfonamides or thionyl amines are a privileged class of pharmaceutical compounds with a broad spectrum of activities. They are widely used as antibacterial agents, diuretics, anticonvulsants, HIV protease inhibitors. The research focus on the synthesis of sulfonamides or thionyl amines. In recent years, the activation of dimethyl sulfoxide (DMSO) for the synthesis of organic compounds has become a hot topic. The DMSO was used as inexpensive reagent with primary amines, second amines, tertiary amines, amides to construct S-N bond via screening catalyst and oxidant. The formation of S-N bond and intramolecular cyclization such as benzylamine, benzamide, amphetamine with DMSO will be studied in order to expand the synthetic routes and methods. The reaction of DMSO with o-ethynylaniline, o-aminobenzoic acid, o-aminobenzyl alcohol will be investigated so as to provide convenient methods for the synthesis of sulfonamides or thionyl amines. The synthesis or structural modification of some commercial drugs will be obtained via the activation of dimethyl sulfoxide (DMSO) functionalization methods. The results will provide convenient methods for the synthesis of commercial drugs or their intermediates and have potential application.