新型抗粘附、自清洁超浸润性齿科陶瓷界面材料研究

齿科陶瓷材料（以氧化铝和氧化锆类陶瓷为主）具有良好的力学和美学性能，是牙齿缺损、畸形等疾病诊疗所需的材料主体，但其表面易于细菌定植，导致临床应用中牙齿脱矿、龋病、牙周病等医源性并发症高发。本项目从表面微观结构和化学组成两个方面入手，联合应用磁控溅射、蚀刻、气相沉积等技术在齿科陶瓷材料表面构筑多尺度特殊浸润性微纳米结构；进一步通过组装技术优化与分子结构筛选，在微纳米表面负载聚乙二醇及甜菜碱等仿细胞膜外层抗粘附分子；解析功能化后的齿科陶瓷材料表面特殊浸润性形貌调控机制及选择性负载功能分子机理，阐明材料表面结构与组分协同影响浸润性、抗粘附、自清洁的规律，建立起与之符合的新的超浸润理论与模型；筛选出最佳工艺参数及制备方案，研制2-3种兼具表面微纳结构与仿细胞膜外层抗粘附组分的、稳定超浸润性齿科陶瓷界面材料，开展体内、外功能验证，实现口腔细菌与食物残渣粘附等病源因素的源头治理。

Dental ceramic（aluminiun oxide and zirconium oxide）, taking advantages of combining esthetics and mechanics, is one of the most important materials required in dental clinic. However, the serious bacteria colonization and food residues retention on bioceramic has yielded high risk of iatrogenic complications, such as tooth demineralization, dental caries and periodontitis. To address this challenge, this project focuses on developing new anti-adhesion, self-cleaning bioceramic with the superwetting interfacial modification techniques. First of all, micro- and nano- scale structures will be fabricated on dental ceramics with magnetron sputtering, etching or vapor deposition techniques. Secondly, the anti-adhesion biomolecule including PEG and betaine, simulating outer layer of cellular membrane, will be binded on the as multiscale structures to achieve interfacial superwettability. The regulatory mechanism of multiscale structures formation and its efficiency on selective loading functional molecules will be analyzed. The synergistic effect of structures and biomolicules on the final interfacial wettability, anti-adhesion and self-cleaning will be systematically investigated. Counted on the results of in vitro and in vivo functional validity testification, the design and fabrication techniques will be optimized. We aimed to achieve 2-3 kinds of new superwetting, anti-adhesion and self-cleaning dental ceramic interfacial materials to eliminate the pathogenic factors such as bacteria and food residues from the very beginning.