可替代HEMA 的Janus纳米复合材料的合成与功能

直接粘接修复技术是牙体缺损修复的主流方法。但粘接剂中促进亲水疏水组分混溶的增溶剂HEMA存在三大问题：亲水性过强、仅含一个双键、存在细胞毒性。寻找HEMA替代物成为亟待解决的问题。本课题组以往研究发现具有双亲性的Janus材料是解决不相溶组分间界面问题的理想材料，通过对Janus纳米材料表面改性，可获得具有特殊功能的Janus纳米材料。本研究将借助Pickering乳液法和纳米颗粒原位蚀刻改性技术制备疏水侧含可聚合双键的双亲性Janus纳米材料。调控Janus平衡性参数解决亲水性过强的问题，疏水侧接枝多个双键提高交联密度，使用生物相容性好的纳米二氧化硅作为Janus材料的主体降低细胞毒性。研究结果将有助于形成更稳定的粘接界面，提高修复体使用寿命。本研究首次将Janus材料的理念引入口腔医学研究领域，涉及高分子物理与化学、口腔医学、纳米科学研究，为解决口腔医学问题提供了全新的视角。

Tooth adhesive technology using composite resin is the major technology for tooth defect restoration. However, dental adhesives contain HEMA (2-hydroxyethyl methacrylate) as solubilizer, it have three disadvantages: enhanced water-sorption, only have one polymerizable groups that susceptible to hydrolysis, high toxicity. Because of these disadvantages, its imperative to get the HEMA substitution. It had been verified that amphiphilic Janus materials is the ideal materials for interface issues, and the surface modification with special features could be obtained. The Janus nano-composites with unsaturated double bond in hydrophobic side would be prepared by technique of pickering emulsion and etching modification in situ of nano-composites. Regulating the Janus-balance could solve the problem of enhanced water-sorption. By adding the unsaturated double bond in hydrophobic side could increased the cross-link density. Using biocompatible nano silicon dioxide as the subject of Janus nano-composites could reduce cytotoxicity. The research would contribute to a more stable bonding interface and improve the service life of the composite restoration. This research firstly introduce the Janus concept into the stomatology, involving polymer physics and chemistry, stomatology and nano-science. It provide a new perspective for stomatology.