受气候及生态环境变化、全球化和城市化等因素的影响，近年来以我国广东和云南为代表的重点省份登革热疫情呈现多点暴发态势，不仅构成了严重的公共卫生问题，也给当地传染病防控体系构成了严峻挑战。然而，登革热传播机制复杂，不但涉及登革病毒-媒介伊蚊-人群相互作用，而且受自然及社会因素的影响。目前，多维度因素在我国云南和广东登革热发病中的贡献率及其驱动发病的机制尚不清楚，并且我国精准的登革热应对机制也尚未建立。本项目通过在我国登革热发生重点省份广东和云南系统地收集影响该病发生的生态、生物和社会因素，采用主成分回归和结构方程模型相结合的方法，揭示生物-生态-社会因素在我国重点省份登革热发病中的贡献率及其驱动发病的机制，并研究具有地方特色的登革热精准应对机制的建立、实施、评价和优化。该研究的开展不仅可为今后我国登革热的科学防控提供依据，也可为我国其他登革热流行区应对机制研究提供模式参考。

Under the impact of climate change, the deterioration of ecological environment, globalization and urbanization, the multipoint outbreak of dengue fever in Guangdong and Yunnan, the representative southern provinces in recent years, not only constitutes the serious public health threat, but also poses the serious challenge to the current communicable disease prevention and control system. However, dengue transmission mechanism is very complicate, it not only relates to the interactions among dengue virus，vector Aedes and humans, but also impacted by natural and social factors. At present, it is not clear whether there is a difference of the contribution rate of co-existence of driving factors in Guangdong and Yunnan, and the precise coping mechanism is still not established. Based on the systematic collection of dengue related ecological, biological, and social factors, then principal component regression (PCR) and structural equation modeling (SEM) methods will be conducted to explore the contribution rate of eco-bio-social factors and mechanism how eco-bio-social factors drive dengue in Guangdong and Yunnan, based on the findings mentioned above, then we study and try to establish, evaluate and optimize the precise coping mechanism in key provinces of China. The findings of the current study will not only provide a basis for the precise and scientific dengue prevention and control strategy in the future, but also provide references of research model in other dengue epidemic regions in China.