本项目拟采用以新型手性双功能小分子催化剂为目标导向策略，通过对手性双功能小分子催化剂适当位置进行结构改造，合成新型高效、具有自主知识产权的新型手性双功能小分子催化剂。通过积极寻找模板反应，将设计合成的新型手性双功能小分子催化剂用于苯酚与不活泼醛的不对称Oxy-Michael合成方法学中。继而将优化的高收率、高对映选择性的不对称合成方法学作为关键技术应用于手性药物如(R)-Tomoxetine等药物的合成中，为发展具有实用价值的手性药物合成新路提供方法学支持。从而丰富手性双功能小分子催化剂种类，满足科研与生产的需要。

This project intends to use the new chiral bifunctional small molecules catalysts for target oriented strategy. Highly efficient and independent intellectual property rights of the new chiral bifunctional small molecules catalysts will be synthesized based on structural modification in the proper position. Asymmetric synthesis methodology of phenol and unsaturated aldehydes will be studied with new chiral bifunctional small molecules catalysts through template reactions. Then the optimization of high yield and high enantioselective asymmetric synthesis methodology as the key technology will be used in chiral drug synthesis such as (R)-Tomoxetine，which will provide methodology support for the development of practical synthetic route for chiral drugs. This project can enrich the source of chiral bifunctional small molecules catalysts and meets the requirement of scientific research and production.