在听觉神经系统中，下丘是最重要的双耳听觉信息整合核团之一，但至今对下丘的双耳信息整合机制的认识极为有限，特别是在清醒动物单神经元水平或突触水平上的研究很少。基于我们前期和近期研究工作的基础以及对听觉系统双耳信息整合研究文献的理解，我们认为同侧耳输入的增益调节可能在下丘神经元的双耳听觉信息整合过程中起到非常重要的作用。本课题组经过多年的探索，目前已经掌握了一套稳定的清醒小鼠听觉系统单神经元贴附式记录和在体全细胞记录方法。借助这一实验技术，我们拟从单神经元动作电位水平和突触后电位水平深入地研究清醒小鼠下丘神经元双耳听觉信息整合特性。从而系统地揭示小鼠下丘双耳听觉信息整合过程中同侧耳输入的增益调节机制，以及这种机制在不同特性神经元中的表现。我们的研究结果将为听觉信息的下丘处理机制贡献新理论。

Inferior colliculus (IC) is a critical center for the binaural processing of auditory information, but the binaural processing mechanism and the underlying synaptic mechanisms remain not well understood, especially in awake animals. Basing on our previous and recent experiment research and literature research of these mechanisms, we presume that the Ispilateral gain control plays a very important role in IC's binaural auditory processing.After years of exploration, our group have mastered cell-attached loose-patch recirdings and in vivo whole-cell recordings method for awake mouse.Basing on our experiment technology, we are going to deeply study IC's binaural auditory processing mechanisms with spike level and EPSP level on awake mouse.As a result we may reveal systematically the Ipsilateral gain control mechanisms of binaural auditory processing in inferior colliculus of awake mouse, as well as who they present in different neurons.Obviously, our results will contribute new theoretical to understand the mechanism of IC's processing for auditory information.