Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex.
Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex.
复制标题
通过听觉皮层的活跃行为状态减少平衡兴奋和抑制
DOI：
10.1038/nn.3701
复制
发表时间：
2014-06
影响因子：
25
通讯作者：
Zhang, Li I.
中科院分区：
文献类型：
--
作者：
Zhou, Mu;Liang, Feixue;Xiong, Xiaorui R.;Li, Lu;Li, Haifu;Xiao, Zhongju;Tao, Huizhong W.;Zhang, Li I.
皮层感觉处理受行为和认知状态的调节。这种调制是如何通过改变突触回路来实现的，这在很大程度上仍不清楚。在清醒的小鼠听觉皮层，我们发现，感觉诱发的棘波反应层2/3（L2/3）兴奋性细胞按比例缩小与保存的感觉调谐时，小鼠从静止过渡到活跃的行为，包括运动，而L4和丘脑的反应是不变的。全细胞电压钳记录显示，音调诱发的突触兴奋和抑制表现出强大的功能平衡。在L2/3细胞中，激活状态的改变导致兴奋和抑制在近似相等的水平上按比例缩小，但在L4细胞中没有导致突触变化。这种层特异性增益控制可归因于L1介导的抑制性音调的增强，L2/3小清蛋白抑制性神经元也被抑制。因此，L2/3电路可以根据瞬时行为需求调整输出的显著性，同时保持感觉处理的灵敏度和质量。
Cortical sensory processing is modulated by behavioral and cognitive states. How this modulation is achieved by changing synaptic circuits remains largely unknown. In awake mouse auditory cortex, we found that sensory-evoked spike responses of layer 2/3 (L2/3) excitatory cells were scaled down with preserved sensory tuning when mice transitioned from quiescence to active behaviors, including locomotion, whereas L4 and thalamic responses were unchanged. Whole-cell voltage-clamp recordings revealed that tone-evoked synaptic excitation and inhibition exhibited a robust functional balance. The change to active states caused scaling down of excitation and inhibition at approximately equal levels in L2/3 cells, but resulted in no synaptic changes in L4 cells. This lamina-specific gain control could be attributed to an enhancement of L1-mediated inhibitory tone, with L2/3 parvalbumin inhibitory neurons also being suppressed. Thus, L2/3 circuits can adjust the salience of output in accordance with momentary behavioral demands while maintaining the sensitivity and quality of sensory processing.
登录
查看更多内容
影响因子：
16.2
作者：
Bennett C;Arroyo S;Hestrin S
通讯作者：
Hestrin S
影响因子：
25
作者：
Dantzker, JL;Callaway, EM
通讯作者：
Callaway, EM
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
25
作者：
Otazu, Gonzalo H.;Tai, Lung-Hao;Yang, Yang;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
影响因子：
64.8
作者：
Petreanu, Leopoldo;Mao, Tianyi;Svoboda, Karel
通讯作者：
Svoboda, Karel