《自然》杂志近年来多次报道医同放射性同位素短缺危机，研究用于生产同位素的新途径迫在眉捷。光核同位素嬗变被视为一种非常有效和现实的途径来提供各种放射性同位素，用于核医学、分子影像学、分子生物学，以及其它基础科学和应用研究。本项目研究利用激光等离子体加速－轫致辐射源驱动光核反应产生医用感兴趣的同位素，选取钼、铜、锗、镓和钛靶为嬗变对象，针对激光加速电子诱发的光核反应机制及放射性同位素产生物理过程开展理论和实验研究。理论上扩展和开发含光核反应程序模块的蒙特卡罗模拟程序，研究并阐明同位素活度与激光加速电子－轫致辐射源参数、同位素靶几何、辐照时间等关键物理量的内在关联，提出利用太瓦激光装置开展医用同位素研究的优化实验方案，实验上将在上海交通大学的200太瓦激光装置上开展上述实验，探究基于激光等离子体加速的放射性同位素“桌面”产生新途径和潜力，以及拓展全光学的激光辐射源在核医学等领域的前沿应用。

Recently, Nature magazine reported that medical radioisotope shortage reached crisis level. It is crucial to take urge actions on novel pathways for the producion of medical isotopes. Photonuclear isotope transmutation is shown to be a very efficient and realistic way to provide various kinds of radioisotopes to be used for nuclear medicine, molecular imaging, molecular biology and for other basic and applied science. This project arms to generate photo-nuclear radioisotopes of medical interest by using laser-plasma-based Bremsstrahlung gamma source. Taking Molybdenum-100, Copper-65/Copper-63, Germanium-70, Gallium-69, and Titanium-48/Titanium-46 as transmuted targets, photonuclear reaction mechanism induced by laser accelerated electrons and the resulting physical processes on the production of radioisotopes will be investigated theoretically and experimentally. The theoretical study will be mainly performed on the development of Monte Carlo simulation program by considering photonuclear reaction algorithms and then on the underlying correlations between radioisotope activity and the main characteristics of intense laser-driven electron-Bremsstrahlung source, isotopic target geometry, and irradiation time. An optimal experimental scheme for the study of medical isotopes by using TW-class laser system will be proposed. The consequent experiments will be conducted at the 200 TW laser facility of Shanghai Jiaotong University, by which novel table-top pathways and its potential on the generation of radioisotopes of medical interest from laser-plasma accelerator will be explored. These studies are beneficial to the application of all-optical laser-based radiation source in nuclear medicine.