本项目以化学结构简单稳定且生物相容性良好的聚硅氧烷为基础原料，以多种带电荷的离子基团为核心单元，探索简单高效制备离子型聚硅氧烷的方法，并以此构筑具有生物活性、高强韧、动态可修复的聚硅氧烷水凝胶结构材料。具体研究内容包括：利用温和高效的巯基-双键click反应和Michael加成反应对聚硅氧烷侧链进行功能性离子基团的修饰，制备一系列具有不同电荷数量、不同离子基团的离子型聚硅氧烷；利用多类型离子型聚硅氧烷间的强静电相互作用制备一系列高强韧超分子水凝胶材料；利用双网络凝胶和复合凝胶的方法进一步对离子型聚硅氧烷水凝胶体系增韧增强，同时实现其对聚电解质生物大分子及带点纳米粒子的负载，拓宽其应用前景。重点研究聚合物分子量、离子基团种类、浓度、摩尔比例以及外部刺激因素等对目标水凝胶体系力学性能的影响。

In this proposal, we attempt to use biocompatible polysiloxanes and a variety of ionic groups with different charges to explore the simple and efficient methods to synthesize ionic polysiloxanes, and to prepare the bioactive, tough and dynamic repairable structural hydrogels based on the ionic polysiloxanes. Firstly, we utilize the mild and efficient thiol-ene click reaction and Michael addition reaction to modify the side chains of functional polysiloxanes, and synthesize a series of ionic polysiloxanes with different ionic groups and electric charges. Then, based on the strong electrostatic interactions between ionic polysiloxanes, the highly both tough and soft supramolecular hydrogels will be constructed and their self-healing abilities will be further studied. Finally, the mechanical properties of ionic polysiloxane hydrogels could be enhanced and modulated by the formations of double network hydrogels and hydrogel composites. Meanwhile, the polysiloxane hydrogel system could show their potential biomedical applications by loading natural polyelectrolytes and ionic nanoparticles. We will focus on the influences of the molecular weight of polysiloxanes, the types, concentrations and molar ratio of ionic groups, and the external stimulus on the mechanical properties of target hydrogel systems.