本项目以天然高分子淀粉为研究对象，以淀粉大分子结构设计、自组装及功能化为基础，稳态化脂溶性功能因子为导向，系统研究淀粉结构与载体特性的构效关系及释放性等基础科学问题，实现该组装可控功能化。项目基于淀粉的链结构及聚集态特点，对其进行修饰，并与亲水胶体复配，构建淀粉-亲水胶体载体，从分子层面上调控淀粉链结构和聚集态，明确淀粉品种、修饰手段、复配比例和条件与载体水解特性之间的相关性，探究不同结构的淀粉与亲水胶体在复配过程中的作用机制；以共轭亚油酸为靶向目标模型，采用自组装界面反应将其载入至载体，研究其稳定性，体内外实验建立共轭亚油酸的释放动力学模型，确定释放机制；通过分子动力学技术设计载体结构，探索能明显改变载体稳态化共轭亚油酸的调控策略，提高脂溶性功能因子的生物利用度和稳定性。

This project uses starch, a natural polymer, as study material to comprehensively investigate the correlations between starch structure and carrier characteristics as well as its releasing property with the aim to manipulate its functionality. The study is based on design, self-assembly and manipulation of starch macromolecular structure with the target of stabilization of lipid-soluble functional molecules. The project will modify the starch structure based on chain structure and its aggregation behavior; develop a starch-hydrocolloid complex carrier through complexing starch with guar gum; manipulate starch chain structure and state of aggregation at molecular level; establish the relationship between carrier hydrolysis characteristics and the roles of starch botanical sources, modification methods, the ratio of starch and hydrocolloid, and the complexation conditions; and investigate the mechanism of interactions between starch of various structures and hydrocolloids. The project will use the conjugated linoleic acid as target model and load it into the starch carrier through self-assembled interfacial reaction. The stability, in vitro and in vivo releasing property of conjugated linoleic acid and its releasing mechanism will be determined. The objective of this project is to design carrier structure using molecular dynamics techniques, explore the possible carrier solutions for significantly stabilizing the conjugated linoleic acid and increase the bioavailability and stability of lipid-soluble functional molecules.