基于非共价键定量调控的手性超分子凝胶精准构筑及其组装机制研究

手性超分子凝胶因在手性模板、生物医药和手性光学等材料领域具有巨大的应用潜力而备受关注，其手性组装结构的精准构筑已成为手性科学研究的热点和前沿。利用非共价键的动态可逆性及刺激响应性，对超分子手性进行调控是获得精确手性结构的重要手段，但缺乏明确的定量调控机制，手性组装结构的高效、精准构筑依然面临巨大的挑战。本项目以阐明超分子手性精确调控的普适性机制为核心，从定量的思路开展相关基础研究。通过对手性POSS核树枝状大分子的分子间非共价键和组装过程动力学进行调控，获得手性光学、组装行为、组装结构和凝胶性能的变化规律，构建动力学因素约束下的非共价键（大小、方向和作用点）与手性特征（螺距、螺旋外径）间的相关定量模型，揭示手性的传递、放大和表达的基本规律，阐明超分子手性精确调控的普适性机制，发展手性超分子凝胶精准构筑的技术和原理，为手性物质的实际应用奠定坚实的理论基础，为手性科学问题的研究提供全新的思路。

Chiral supramolecular gels have attracted much attention due to their huge potential applications in chiral functional materials such as chiral templates, biomedicine and chiral optics. The precise construction of chiral assembly structure has become a hot topic in chiral science. Take advantage of the dynamic reversibility and stimulus responsiveness of the non- covalent bond to regulate supramolecular chirality is an effective method to obtain specific chiral structures. However, the quantitative supramolecular chiral regulation mechanism still maintains in ambiguous, the efficient and precise construction of supramolecular chiral structure remains a challenge. This proposal is aim at to elucidate the universal mechanism of precise regulation of supramolecular chirality in a quantitative research approach. Firstly, through regulating the intermolecular non-covalent bond and the kinetic assembly process of a chiral Polyhedral Oligomeric Silsesquioxane (POSS)-based dendrimer, ascertaining the change rules of the chiral optics, the characteristics of the assembly structures and the properties of gels. Meanwhile, constructing the correlation quantitative model between the non-covalent bond (size, direction and operational point) and the chiral characteristics (pitch and outer diameter of screw) under the constraint of kinetic factors. After that, revealing the basic laws of chiral transfer, amplification and expression during regulation process, and elucidating the universal mechanism of precise regulation of supramolecular chirality. Eventually, developing the novel method and principle for precise constructing supramolecular chiral gels through controlled self-assembly techniques. The successful implementation of this project will lay a solid theoretical foundation for the application of chiral materials and provide novel ideas for the research of the science of chirality.