内植物术后感染是骨科临床亟待解决的难点问题。因内植物的存在及伴随的细菌生物膜形成，常规途径使用抗生素，治疗效率低下，通常需再次手术。提高抗生素在骨组织内的药物浓度，增强其对细菌生物膜形成的抑制是早期控制感染，保留内植物的关键。将抗生素与生物材料结合制备具有骨靶向功能的抗生素缓释体是解决上述问题的可行方案。依诺沙星具有抗菌及抑制破骨细胞的双重作用功效，在骨关节术后感染的治疗中既能抑制细菌生长，又可防止感染后骨丢失及继发的内植物松动。为使药物在骨内靶向释放，本研究以介孔二氧化硅纳米颗粒为载体负载依诺沙星并于颗粒表面连接特异性骨识别基团——天冬氨酸八肽(ASP8)。前期研究发现：制备的介孔纳米材料对依诺沙星具有良好的负载和缓释性能以及骨靶向特性。在此基础上，我们拟深入研究该药物缓释体的抗菌、抑制破骨细胞及在体内防治感染和感染后骨丢失的作用效果，以期为骨关节术后感染的防治提供新的治疗手段。

Postoperative infection is an intractable issue, which should be resolved immediately in orthopeadic clinics. For the exist of implantation and following formation of bacterium biofilm, it is low-efficiency to treat infection with a traditional usage way of antibiotics, and usually, implantations will be get out in a second operation. It’s the key point to limit infection earlier and preserve implantations by improving antibiotic concentration in the bone and enhancing the inhibitory effect on bacterium biofilm formation. Combining antibiotic with biomaterial, then preparing a novel antibiotic-released system is an available way to overcome this problem. With double effects of antibacterial and inhibiting osteoclast formation, enoxacin plays critical roles both in limiting infection and preventing bone loss, and the following implantation loosen when treating bone and joint postoperative infection. For the aim enoxacin will specifically release in the bone, in this research, enoxacin was loaded on mesporous silicon dioxide nano-particles, and bone-specifically recognized group, ASP8 was conjunct on these particles. Our previous research represented that the preparing mesporous nanomaterial had excellent drug loading, releasing and bone-targeting property. Based on the previous results, we planned to conduct a further research about the effect of this released system on antibacterial, inhibiting osteoclastogenesis, preventing and treating bone infection, as well as bone loss in vivo, for the purpose to create a novel approach to treat bone and joint postoperative infection.