钌络合物催化的炔类化合物内型环异构化反应及相关反应研究

根据申请人前期所发展的新型四齿配体钌络合物催化的炔醇内型环异构化反应，本研究项目将进一步探索含有别的亲核基团的炔类化合物的内型环异构化反应。并通过加入碱和亲电试剂，进一步将炔醇内型环异构化反应发展为新的可以一锅合成α-取代环烯化合物的催化反应。另外，基于已经探明的四齿配体钌络合物与炔基反应的机理，利用催化反应的活性中间体进一步与分子内或分子间的活性基团反应，发展出一系列钌络合物催化的串联催化反应和协同催化反应，大大拓宽钌络合物催化的反应类型，并可一锅生成结构复杂的杂原子多环或稠环分子结构，为天然产物和药物分子的合成提供新的策略和方法。

On the basis of the endo-cycloisomerization of alkynols catalyzed by the novel tetradentate ligand coordinated ruthenium complex, this project would further investigate the endo-cycloisomerization of a series of alkynes incorporating other nucleophilic groups, and develop the catalytic reactions to generate the α-substituted cyclo-alkenes via the one-pot cycloisomerization added with base and electrophiles. Moreover, based on the known mechanism for the reaction of ruthenium complex with alkynes, this project would develop a series of ruthenium complexes catalyzed synergistic reactions and cascade reactions, through the reactions of the catalytic intermediates with the intramolecular or intermolecular active groups. This protocol would greatly multiply the ruthenium complexes catalyzed reactions and generate the complicated heterocycle structures via one pot reactions, which would provide new strategies and methods for the total synthesis of the natural products and the synthesis of the drug compounds.