胶质瘤是当前危害人类健康的主要杀手之一，其主要原因是早期诊断的成功率较低，并且对进展和转移等机制还缺乏全面清晰的认识。目前，对胶质瘤的诊断研究进展处于及早检测与诊断的阶段，主要是从分子生物学角度出发。如果能够在细胞或亚细胞层次上进一步识别或进行判断，将可能大大提高癌症及早诊断的确定性。将胶质瘤转移机制与相关检测方法的研究相结合，有助于缓解和应对当前高发与不易控制这些难题。本项目发展和使用先进的多功能微纳热电偶以及磁性纳米材料等微纳器件与材料，结合相关的生物化学、细胞生物学方法，针对胶质瘤转移以及分级等开发检测分析的新途径，并探索疾病早期诊断的新方法。为基于纳米材料的分子电子学和新型生物医学器件及其应用的开发奠定了基础。

Glioma is a major killer among all human disease, mainly because the success rate of early diagnosis is low. A comprehensive understanding of glioma progression and metastasis mechanisms still needs clarifying. At present glioma diagnosis researches have progressed to early detection and diagnosis stage, most of which bases on molecular biology. If we can study the cell at the cell or sub-cell level, the accuracy of the cancer early detection will be greatly enhanced. By uniting the study of glioma metastasis mechanism and related inspection methods, it is possible to improve the high incidence of glioma at present and deal with the problems in disease control. This project developed and utilized the advanced micro-nano devices and materials such as multifunctional micro/nano thermocouple and magnetic nano-materials, in combination with biochemistry and cell biology for studying glioma, and meantime investigating new inspecting methods for glioma metastasis and tumorous grading/staging, thus to explored new approaches for early diagnosis in human disease. The project will lay a foundation for the research of nanomaterial-based electronics and novel biomedical devices.