手性药物分子的选择性识别和检测非常重要，导电高分子中引入手性氨基酸侧链可形成手性螺旋结构，对手性化合物具有识别作用，但这方面国内外报道甚少。本项目拟合成含手性氨基酸侧链的3,4-乙撑二氧噻吩（EDOT）单体，然后经化学或电化学聚合制备手性氨基酸修饰的新型手性导电聚（3,4-乙撑二氧噻吩）（PEDOT），并利用聚合物对电极的良好附着性，探索其修饰电极作为电化学传感器对手性药物的检测效果。系统研究不同手性氨基酸取代、单体结构、聚合条件和方法等对聚合物的结构、构型和性能的影响规律，掌握手性氨基酸修饰PEDOT的化学或电化学聚合工艺，建立手性药物的电化学检测方法。本项目把PEDOT的高电导率、优良氧化还原活性和环境稳定性等性能与手性氨基酸的旋光性、良好生物兼容性等性质结合起来，制备手性氨基酸修饰的导电PEDOT，并将其应用于手性药物的分析检测，对手性导电高分子的发展及应用研究具有重要意义。

The selective recognition and determination of chiral drug molecules are very important. Introduction of chiral amino acids side chains to the conducting polymer can form a chiral helical structure and recognize chiral compounds, but this has rarely been reported worldwide. This project is designed to synthesize 3,4-ethylenedioxythiophene (EDOT) monomers that contain chiral amino acids side chains, prepare chiral amino acids modified novel chiral conducting poly(3,4-ethylenedioxythiophene) (PEDOT) via chemical or electrochemical polymerization, and then explore the determinative effects of chiral drugs on the polymer modified electrode as electrochemical sensors. In the project, the influence of different chiral amino acid substitutions, structures of monomers, conditions and methods of polymerization on the structures, configurations and properties of polymers will be systematically studied. In addition, the chemical or electrochemical polymerization process of the chiral amino acids modified PEDOT will be explored, and the chiral drugs' electrochemical determination method will be established. The project is likely to be the first one to integrate the high conductivity, excellent oxidation activity and environmental stability of PEDOT with the optical activity, good biocompatibility of chiral amino acids to synthesize chiral amino acids modified conducting PEDOT and analyze chiral drugs, which will be critical in the development and application of chiral conducting polymer.