石墨烯易团聚，难溶于水和普通有机溶剂，对氧化石墨烯（GO）改性，提高其分散性，是实现石墨烯功能化并拓展其应用的最为有效的途径之一。本项目拟采用含官能团侧链的3,4-乙撑二氧噻吩（EDOT）及其聚合物PEDOT对GO进行共价键和非共价键改性，将其与EDOT单体或PEDOT通过化学聚合、共混、电化学原位聚合三种方法制备导电PEDOT/GO复合材料，并探索其修饰电极作为电化学传感器应用于大环内酯类抗生素（MALs）的分析检测。系统研究EDOT单体和聚合物结构与改性方法对改性GO性能的影响规律，掌握导电PEDOT/GO复合材料的制备工艺，建立单种和多种MALs同时分析检测的方法。本项目首次用侧链修饰的EDOT及其聚合物改性GO，将GO的良好生物兼容性与PEDOT的优良性能结合制备PEDOT/GO复合材料，并首次将其应用于MALs的分析检测，对GO纳米复合材料的发展及应用具有重要意义。

Graphene is easy to agglomerate and is insoluble in water and common organic solvents. Modification of graphene oxide (GO) to improve its dispersion is one of the most effective way to achieve the functionalization of graphene and expand its application. This project is designed to modify the GO through covalent and non-covalent bonds by 3,4-ethylenedioxythiophene (EDOT) and its polymer PEDOT with functional group side chains, then polymerize the modified GO and the EDOT monomers or PEDOT via chemical oxidative polymerization, blending or in-situ electrochemical polymerization to prepare conducting PEDOT/GO composites, and explore the detection of macrolide antibiotics (MALs) using the composites to modified electrodes as electrochemical sensors. In the project, the influence of the structures of EDOT monomers and polymers and modified methods of GO on properties of GO will be systematically studied. In addition, the preparation process of the conducting PEDOT/GO composites will be explored, and the detection method of single and various MALs will be established. The project is likely to be the first one to modify GO using the side chain functional EDOT and its polymers. The project is also likely to pioneer in the integration of the good biocompatibility of GO and the excellent performances of the PEDOT in the preparation of PEDOT/GO composites and detection of the MALs. These will be critical in the development and application of GO nanocomposites.