目前颈动脉狭窄患者的脑网络及认知功能改变及其机制并不明确。我们前期研究发现颈动脉狭窄所致脑低灌注可引起认知功能损害，而颈动脉内膜剥脱手术可改善患者认知功能。同期研究中本课题组发现脑卒中可造成患者脑网络破坏，进而引起认知功能损害。所以我们拟应用脑网络融合技术分析、处理弥散张量成像（DTI）、静息态功能磁共振（rs-fMRI）、任务态功能磁共振（task-fMRI）扫描颈动脉狭窄患者所得的脑网络影像数据，建立颈动脉狭窄患者的多模态融合脑网络，结合脑认知功能检查及脑灌注评估，与健康成人对比研究，明确颈动脉狭窄患者认知功能及其脑网络发生的改变；探明部分受损认知功能与被破坏脑网络的关联关系，发现潜在的认知脑环路；同时分析患者手术后脑网络、脑灌注及认知功能改变情况，验证前期研究发现的认知功能脑环路。为颈动脉狭窄伴认知功能障碍患者的治疗策略提供理论基础，为认知功能研究、脑网络研究提供支持。

Changes in brain networks and cognitive function in patients with carotid stenosis were not clear. Based on previous studies, we found that hypoperfusion caused by carotid stenosis can lead to cognitive impairment. And carotid endarterectomy can improve the cognitive function of patients. Another study found that stroke can cause brain network damage, which can lead to cognitive impairment. So we proposed to use diffusion tensor imaging technology, resting state fMRI, task based fMRI and the brain network fusion technology to establish a multimodal fusion network of carotid stenosis patients. Combined with cognitive function estimate and brain cerebral perfusion evaluation, in comparison with healthy adult controls can we find changes in patients brain network and cognition. To identify the relationship between the impaired cognitive function and the damaged brain network, we can discover the potential cognitive brain circuits. At the same time, the brain network, cerebral perfusion and cognitive function changes before and after the operation were compared, and the cognitive functional brain circuits found before were further verified. This experiment provides a theoretical basis for the treatment strategies of patients with carotid artery stenosis with cognitive dysfunction. And provides evidence for brain cognition and brain network study in future.