研究高效、环境友好的化学毒物（催化）洗消材料，对于保护人类环境安全具有非常重要的意义。借鉴于细菌菌株中磷酸三酯酶对神经性毒物的优异消解性能，本项目拟设计、合成由类酶结构基元金属-羟基-金属（M-OH-M）构成的金属-氧簇作为次级建筑单元与功能性有机配体链接，生成多孔性仿生催化剂材料。该类材料将借助带正电性的路易斯酸金属位点和M-OH-M的结构基元，能够允许毒剂分子自由出入的可调节的多孔结构，有机配体上连接的富电性亲核官能团或光活性（光照能产生单线态氧）有机配体自身对毒剂具有的消解活性等的共同作用，和/或进一步在所得多孔材料中负载对化学毒物分子具有消解性能的其它无机组分，得到对神经性毒剂和糜烂性毒剂均有优异消解性能的多功能催化剂材料。本项目将为消解催化材料最终投入使用打下坚实的理论和物质基础。

Development of broad-spectrum and high-effect and eco-friendly materials for (catalytic) decontamination of toxic chemical agents is of great importance for the protection of the human environment and the prevention of future activities of terrorist forces. Inspired by the phosphotriesterase featuring the Zn-OH-Zn functional groups that can decontaminate effectively toxic chemical agents, this project proposes to design and synthesize porous biomimetic catalyst materials based on clusters composed of M-OH-M groups as secondary building units which are linked to functional organic ligands. This type of materials utilize the structural elements of enzyme-like functionality (positively charged Lewis acid metal sites and M-OH-M), the adjustable porous molecular structure allowing toxic molecules to move freely, the electrical nucleophilic functional groups linked to organic ligands and/or photoactive (singlet oxygen can be produced under light irradiation) organic ligands which can endow additional decontamination activities, further, other inorganic functional components loaded in the resulting porous material which can also decontaminate both nerve agents and erosive agents, to get multi-functional catalyst materials. This project will lay a solid theoretical and material foundation for the final practical use of catalytic materials.