传染病控制关键策略之一是早而快预警,从而防患于未然。宁夏南部(尤其西吉县)是多种传染病的高发区,尤其是两种包虫病(细粒棘球和泡球蚴)和结核病的重灾区,给当地人民的健康和经济发展造成严重危害。本课题拟联合不同简单易行检查方法 (血清包虫抗体检查和结核菌素实验)监测两种病原体(包虫卵和结核菌)在青少年中暴露情况(率)，以此间接提供病原体对生活环境污染密度/范围。结合影像学技术在基线调查后连续两年随访,比较不同暴露人群的发病率,不但达到验证预警监测指标的时效和实用性，而且能通过多因素分析找出人群暴露于多病原体侵袭情况下所致易感性增加的风险因素，有的放矢设计预防措施保护高流行区青少年的健康成长。本课题基于前期的工作积累,结合流行区对多种传染病预警措施的迫切需要而设计的既节约资源又简单特异的全新联合预警方案，研究结果服务于多种传染病流行区的防控工作, 前景广阔。

A key strategy for infectious disease control is to design an effective and early warning proposal. Southern Ningxia (Xiji County), is a high incidence of many infectious diseases,particularly two types of hydatidosis (alveolar / cystic echinococcosis, AE/CE) and tuberculosis (TB), which significantly impacted on local public health and economic development.A study based on a combination of the various straightforward methods to monitor the exposure rates of different pathogens (Echinococcus spp.eggs/Mycobacteriuml tuberculinum,MTB) among adolescents is proposed. Outcomes indirectly provide evidences that the living environmental contamination density of studied pathogens. After baseline survey with imaging techniques (ultrasound/x-ray) helps for determination of either AE/CE or TB morbidity, apart from cases to let seek consultation in hospital,remaining participants are recruited to attend cohort follow-up in subsequent year for two times annually.Disclosure of different incidences of pathogen-exposure among teenagers is compared to verify the proposed warning-indicators effectively.In addition, risk factors of susceptibility to infections in students influenced by multiple pathogens are identified by multivariate analysis.This is the important information for targeting at preventive measures to protect young people healthy growth in high prevalence area. The study design represents a big saving of manpower, time and resources, is based on accumulation of our previous work, and is the first combination of urgent need to develop the early warning measures for a variety of infectious diseases.Results serve many preventions/ controls of pathogen-infections in comparable endemic areas globally,prospects are bright.