结直肠癌肝转移患者的化疗相关性肝损伤（CASH和SOS）增加患者术后并发症的发生并降低中远期存活率，因此早期诊断有重要临床价值。但目前尚无早期诊断CASH和SOS的有效方法。我们前期研究结果发现肝细胞破坏会导致肝细胞膜表面OATP和MRP受体表达的改变，从而影响肝细胞靶向对比剂Gadoxetic acid的细胞内代谢，而这种代谢变化可通过T1mapping的纵向驰豫时间定量标记。因此，我们推测应用该对比剂可早期诊断及鉴别CASH和SOS，并同时用于肝脏储备功能监测。本课题拟运用分子影像学和分子生物学手段研究：纵向驰豫时间值与CASH和SOS不同病理分级、肝细胞OATP和MRP分子水平及肝细胞损伤因子（IL-6、TNF-α）的相关性；探索肝脏储备功能的血液指标（ALT、AST、T-BIL、ALB）与 OATP、MRP间关系的规律，从而为结直肠癌肝转移患者制定个体化精准治疗方案。

Chemotherapy induced liver injuries (CASH and SOS) in patients with colorectal liver metastasis increases incidence of postoperative complications and reduce the long-term survival rate, so there is important clinical value on early diagnosis. However, there is no effective way on early diagnosis of CASH and SOS. Our previous study found that when the liver cells damaged, the liver cell membrane transporters organic transit peptide (OATP) and the multi-drug resistance protein (MRP) levels would change. Gadoxetic acid, liver cell targeted contrast agent, in liver cell metabollism was affected and this change could be quantitative maker by T1 mapping with T1 relaxation time. Therefore, we hypothesize that using Gadoxeetic acid-enhanced MRI can diagnose and differentiate between CASH and SOS early, at the same time for moitoring the liver reserve function. However, the mechanism of the research is still rarely understood. This topic will explore the relationship between the values of T1 relaxation time with the pathological grade on CASH and SOS by means of molecular imaging and molecular biology research, and with the expressions of OATP and MRP and the liver cell damage factor (IL-6, TNF-α) at the same time. Also, we hope to find the law of the relationship between the index reflecting the liver reserve function of the blood test（ALT、AST、T-BIL、ALB）with expressions of OATP and MRP. Finally, we can provide an accurate imaging basis for the individualized comprehensive treatment plan for colorectal cancer patients with liver metastases.