病毒感染导致宿主免疫反应是机体对病毒的一种防御机制。目前由于对宿主抗病毒天然免疫的精确调控机制缺乏了解，这已经成为病毒学研究中的重大科学问题。主要穹隆蛋白(MVP)是穹隆蛋白的一个组成部分，它在细胞耐药性、核质运输中起重要作用。目前为止，暂无报道MVP在病毒诱导的宿主免疫应答中起作用。本课题将乙型肝炎病毒(HBV)作为主要研究对象，将阐明MVP在宿主抗病毒天然免疫中的作用机制为研究重点。研究主要内容包括：1、从临床出发研究HBV感染后，病人血液和肝组织中MVP的表达变化规律。2、从细胞，分子水平研究HBV 感染过程中MVP的表达变化规律。3、HBV调节MVP表达的分子机制研究。4、MVP对HBV复制的影响。5、MVP调节干扰素产生机制的相关研究。6、MVP与其它病毒感染之间的关系研究。通过多种技术手段，从不同的角度阐明MVP在宿主抗病毒免疫应答中的作用机制，为抗病毒药物的研发提供新信息和

Host immune response initiated by viral infections is a defense mechanism of the body. At present, the precise regulatory mechanism of the host antiviral innate immunity is ambiguous, which has made it become　an important scientific question in virological research field. Major vault protein (MVP) is the major constituent of vaults and is involved in multi-drug resistance, nucleocytoplasmic transport, and cell signaling. However, little is known about the role of MVP during viral infections. In this project, we will investigate cellular signaling events which are initiated by hepatitis B virus (HBV) as an experimental model to define the role of MVP in host antiviral innate immune response. The main objectives of this project include: 1, Compare with MVP expression in blood and liver tissue from patients infected with HBV and healthy individuals. 2, HBV induces MVP expression in hepatocyte cell lines. 3, Explore the mechanism behind MVP expression induced by HBV infection. 4, The effect of MVP on HBV replication and infection. 5, MVP regulates interferon production and related cellular signaling events. 6, Clarify the relationship between MVP expression and other viruses infection. Our study will provide new information and strategies for the development of candidate antiviral drug and elucidate the role of MVP in host antiviral immune response by applying different technologies.