诱导组织实现完美的再生医学修复，真正实现植入材料与宿主细胞间的刺激、响应等生物应答行为是临床修复材料及支架的关键科学问题。本项目拟采用PLGA作为骨修复材料的有机相成分，介孔生物活性玻璃作为无机相成分，载有细胞调节因子成骨生长肽（OGP）的质粒DNA为功能基因负载于复合材料之中制备骨修复材料，用以调控复合材料与宿主细胞间的刺激、响应等生物学应答行为，并诱导组织再生修复。研究生物活性玻璃微纳米结构、形貌尺寸、介孔大小等对复合材料力学性能、生物活性、降解速度以及基因调控特性的影响规律及机理，并研究OGP介导骨细胞粘附、增殖、分化的影响及促细胞外基质矿化等再生修复行为的作用机理。通过上述研究将为OGP基因介导型修复材料及支架的设计与制备提供新的思路和理论依据。

The key scientific issues in tissue repair material in clinical to improve the biological stimulus response between repair materials and host cell as well as to induce tissue regeneration. This project will use PLGA as ingredients of the organic phase, mesoporous bioactive glass nanospheres as inorganic phase component, cell regulatory factor osteogenic growth peptide (OGP) plasmid loaded in membrane repair materials to prepare bone repair materials. We will study the influence mechanism of the repair materials by bioactive glass micro and nano structure, morphology, mesoporous size, and the biological activity, the degradation rate and gene mediated tissue regulation characteristics. We will research the bio-responsive mechanism of repair materials and scaffolds by OGP mediated bone cell adhesion, proliferation, differentiation and promote the regeneration of extracellular matrix mineralization. In summary, this study will provide a brand new way and academic evidence for the development of novel OGP gene mediated repair materials and products.